Cardiovascular disease risk in early rheumatoid arthritis: the impact of cartilage oligomeric matrix protein (COMP) and disease activity

Table 4 Impact of traditional CVD risk factors and disease characteristics at inclusion on the risk of CAD

	Crude		Adjusted ^a
Variables at inclusion	HR	95% CI	HR	95% CI
Demographics and anthropometrics
Male sex	2.88	1.67–4.98	2.87	1.65-5.00
Age (per year)	1.07	1.04–1.10	1.07	1.04–1.10
Time to DMARD (per SD) ^b	0.78	0.48–1.25	0.94	0.56–1.58
Traditional CVD risk factors
Hypertension	2.51	1.44–4.35	1.75	0.99–3.12
Diabetes	4.21	1.89–9.38	1.64	0.70–3.81
Hyperlipidaemia	2.14	0.85–5.37	1.25	0.47–3.33
BMI (per SD) ^b	1.02	0.77–1.34	0.93	0.67–1.28
Cigarette smoking status
Never smoking (reference)	1.00		1.00
Current	1.75	0.89–3.45	1.72	0.81–3.65
Previous	1.31	0.64–2.68	0.80	0.35–1.79
Ever	1.52	0.82–2.81	1.22	0.63–2.36
Baseline disease parameters
RF positivity	0.66	0.38–1.13	0.77	0.44–1.34
Anti-CCP positivity	0.79	0.45–1.41	0.95	0.52–1.73
COMP (per SD) ^b	1.51	1.18–1.92	1.35	0.98–1.85
COMP categories
Below median (reference)	1.00		1.00
3rd quartile	2.00	0.98–4.11	1.02	0.47–2.20
4th quartile	2.73	1.36–5.46	1.55	0.75–3.22
DAS28 (per SD) ^b	1.05	0.80–1.38	0.95	0.72–1.25
Disease activity ^c
Moderate/low (reference)	1.00		1.00
High	1.38	0.80–2.39	1.05	0.59–1.88
HAQ (per SD) ^b	1.11	0.85–1.46	1.01	0.76–1.33
ESR (per SD) ^b	1.19	0.93–1.54	1.00	0.76–1.30
CRP below median (reference)	1.00		1.00
CRP above median (> 9 mg/l)	1.56	0.90–2.70	0.92	0.52–1.60

Numbers in bold indicate significance (p < 0.05)
CVD, cardiovascular disease; CAD, coronary artery disease; HR, hazard ratio; CI, confidence interval; DMARD, disease-modifying antirheumatic drugs; SD, standard deviation; BMI, body mass index; RF, rheumatoid factor; Anti-CCP, anti-cyclic citrullinated peptide antibodies; COMP, cartilage oligomeric matrix protein; DAS28, disease activity score in 28 joints; HAQ, health assessment questionnaire; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein
Analyses are based on 52 patients with first ever diagnosis of CAD during follow-up
^a Adjusted for age, sex, hypertension and diabetes at inclusion
^b SD: Time to DMARD 5.1 months; BMI 4.1 kg/m2; COMP 3.6; DAS28 1.4; HAQ 0.62; ESR 26 mm/h
^c For definitions see Table 2

ISSN: 2520-1026