Cardiovascular disease risk in early rheumatoid arthritis: the impact of cartilage oligomeric matrix protein (COMP) and disease activity

Table 5 Impact of disease activity parameters at 2 years and up to 2 years on the risk of subsequent CVD

	Crude		Adjusted ^a
Variables at 2 years	HR	95% CI	HR	95% CI
DAS28 (per SD) ^b	1.14	0.87–1.50	1.26	0.93–1.70
Disease activity ^c
Low (reference)	1.00		1.00
Moderate	0.93	0.52–1.66	0.82	0.43–1.56
High	1.75	0.80–3.81	2.58	1.10–6.04
HAQ (per SD) ^b	1.11	0.85–1.46	1.18	0.90–1.57
ESR (per SD) ^b	1.40	1.10–1.78	1.34	1.02–1.76
CRP below 75th percentile (reference)	1.00		1.00
CRP above 75th percentile (> 12 mg/l)	2.13	1.23–3.69	1.66	0.91–3.05
Variables up to 2 years
DAS28 (AUC per SD) ^b	1.17	0.90–1.54	1.37	1.02–1.84
HAQ (AUC per SD) ^b	1.09	0.83–1.45	1.08	0.81–1.44
ESR (AUC per SD) ^b	1.39	1.10–1.77	1.31	1.02–1.69

Numbers in bold indicate significance (p < 0.05)
CVD, cardiovascular disease; HR, hazard ratio; CI, confidence interval; DAS28, disease activity score in 28 joints; SD, standard deviation; HAQ, health assessment questionnaire; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; AUC, area under curve
Analyses are based on 56 patients with first ever diagnosis of CVD during subsequent follow-up
^a Adjusted for age, sex, hypertension and diabetes at inclusion
^b SD: DAS28 1.4; HAQ 0.65; ESR 18 mm/h; DAS28 AUC 27; HAQ AUC 13; ESR AUC 391
^c For definitions see Table 2

ISSN: 2520-1026