Cardiovascular disease risk in early rheumatoid arthritis: the impact of cartilage oligomeric matrix protein (COMP) and disease activity

Table 6 Impact of disease activity parameters at 2 years and up to 2 years on the risk of subsequent CAD

	Crude		Adjusted ^a
Variables at 2 years	HR	95% CI	HR	95% CI
DAS28 (per SD) ^b	1.24	0.92–1.66	1.38	1.01–1.88
Disease activity ^c
Low (reference)	1.00		1.00
Moderate	1.05	0.54–2.04	1.17	0.59–2.31
High	2.23	0.98–5.05	3.26	1.37–7.73
HAQ (per SD) ^b	1.20	0.90–1.60	1.30	0.96–1.74
ESR (per SD) ^b	1.54	1.23–1.94	1.48	1.16–1.88
CRP below 75th percentile (reference)	1.00		1.00
CRP above 75th percentile (> 12 mg/l)	2.99	1.66–5.40	2.33	1.27–4.28
Variables up to 2 years
DAS28 (AUC per SD) ^b	1.32	0.98–1.78	1.51	1.10–2.07
HAQ (AUC per SD) ^b	1.19	0.90–1.59	1.21	0.91–1.62
ESR (AUC per SD) ^b	1.42	1.09–1.85	1.37	1.04–1.80

Numbers in bold indicate significance (p < 0.05)
CAD, coronary artery disease; HR, hazard ratio; CI, confidence interval; DAS28, disease activity score in 28 joints; SD, standard deviation; HAQ, health assessment questionnaire; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; AUC, area under curve
Analyses are based on 45 patients with first ever diagnosis of CAD during subsequent follow-up
^a Adjusted for age, sex and hypertension at inclusion
^b SD: DAS28 1.4; HAQ 0.65; ESR 18 mm/h; DAS28 AUC 27; HAQ AUC 13; ESR AUC 391
^c For definitions see Table 2

ISSN: 2520-1026