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Fig. 4 | BMC Rheumatology

Fig. 4

From: Decoding the mitochondrial connection: development and validation of biomarkers for classifying and treating systemic lupus erythematosus through bioinformatics and machine learning

Fig. 4

Identification of hub genes for SLE. A-B. RF to screen key characteristic genes. (A) The influence of decision tree number on error rate. (B) Gini importance measure of characteristic MRGs. C-E. LASSO logistic regression to screen key characteristic genes. C. RMSE of key characteristic gene combination. D. LASSO coefficient spectrum of nine genes. E. Optimal penalization coefficient lambda selection. F. Venn diagram of key characteristic genes; overlapping genes selected as hub genes. SLE: systemic lupus erythematosus; RF: random forest; MRGs: mitochondria-related genes; RMSE: root-mean-square error; LASSO: least absolute shrinkage and selection operator

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BMC Rheumatology

ISSN: 2520-1026

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