Table 2 Changes of BASDAI, ASDAS-CRP, ESR and CRP

All patients

Baseline

5.11 ± 1.42(3.25 ~ 7.75)

3.82 ± 1.47(2.83 ~ 4.99)

44.93 ± 23.20(19 ~ 111)

30.47 ± 15.30(10.6 ~ 64.8)

Week 4

31.27 ± 13.91(15 ~ 64)

19.69 ± 10.86(5.8 ~ 46.3)

Week 8

18.33 ± 9.79(2 ~ 33)

11.89 ± 6.42(1.7 ~ 22.3)

Week 12

1.28 ± 0.70(0.20 ~ 2.55)

1.47 ± 0.48(0.75 ~ 2.44)

14.27 ± 10.07(5 ~ 48)

4.99 ± 3.69(0.5 ~ 13.0)

P(week 4, 8, 12 vs. Baseline)

< 0.001

< 0.001

0.060, < 0.001, < 0.001

0.034, < 0.001, < 0.001

Etanercept group

Baseline

5.00 ± 1.42(4.10 ~ 7.10)

3.78 ± 0.72(3.13 ~ 4.79)

53.75 ± 39.14(25 ~ 111)

30.58 ± 13.43(13.3 ~ 44.9)

Week 4

37.00 ± 20.05(19 ~ 64)

15.60 ± 8.10(7.9 ~ 25.5)

Week 8

18.75 ± 9.36(5 ~ 26)

11.00 ± 9.45(3.1 ~ 22.3)

Week 12

1.30 ± 0.77(0.90 ~ 2.45)

1.41 ± 0.52(0.99 ~ 2.10)

21.75 ± 17.58(11 ~ 48)

4.05 ± 3.03(1.0 ~ 6.8)

P(week 4, 8, 12 vs. Baseline)

0.007

0.002

0.475, 0.133, 0.186

0.105, 0.054, 0.008

Infliximab group

Baseline

6.20 ± 1.92(4.05 ~ 7.75)

4.22 ± 1.20(2.83 ~ 4.93)

39.33 ± 17.95(19 ~ 53)

35.50 ± 27.37(10.6 ~ 64.8)

Week 4

23.33 ± 8.50(15 ~ 32)

27.70 ± 20.45(5.8 ~ 46.3)

Week 8

18.00 ± 8.89(11 ~ 28)

11.40 ± 8.43(1.7 ~ 17.0)

Week 12

1.95 ± 0.56(1.45 ~ 2.55)

1.63 ± 0.70(1.14 ~ 2.44)

9.00 ± 1.73(8 ~ 11)

5.20 ± 6.80(0.5 ~ 13.0)

P(week 4, 8, 12 vs. Baseline)

0.021

0.032

0.235,0.139, 0.098

0.713, 0.219, 0.136

Adalimumab group

Baseline

5.27 ± 1.22(4.15 ~ 7.15)

3.99 ± 0.70(3.30 ~ 4.99)

49.60 ± 15.27(38 ~ 76)

33.30 ± 14.31(20.6 ~ 56.4)

Week 4

38.00 ± 10.20(24 ~ 48)

21.00 ± 7.90(15.5 ~ 34.4)

Week 8

25.40 ± 7.16(14 ~ 33)

15.12 ± 2.41(12.1 ~ 18.7)

Week 12

1.25 ± 0.60(0.60 ~ 1.75)

1.67 ± 0.33(1.25 ~ 2.11)

15.40 ± 2.88(12 ~ 20)

7.04 ± 2.39(4.8 ~ 10.8)

P(week 4, 8, 12 vs. Baseline)

< 0.001

< 0.001

0.196, 0.012, 0.001

0.131, 0.023, 0.004

Secukinumab group

Baseline

3.93 ± 0.68(3.25 ~ 4.60)

3.19 ± 0.30(2.91 ~ 3.50)

31.00 ± 11.53(22 ~ 44)

20.57 ± 1.98(18.8 ~ 22.7)

Week 4

20.33 ± 4.16(17 ~ 25)

14.97 ± 4.03(11.8 ~ 19.5)

Week 8

6.33 ± 4.04(2 ~ 10)

8.20 ± 4.80(3.3 ~ 12.9)

Week 12

0.65 ± 0.48(0.20 ~ 1.15)

1.04 ± 0.27(0.75 ~ 1.28)

7.67 ± 2.31(5 ~ 9)

2.60 ± 1.66(0.7 ~ 3.8)

P(week 4, 8, 12 vs. Baseline)

0.002

< 0.001

0.206, 0.025, 0.026

0.097, 0.015, < 0.001