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Table 1 Baseline characteristics of guselkumab-randomized patients

From: Continuous improvement through differential trajectories of individual minimal disease activity criteria with guselkumab in active psoriatic arthritis: post hoc analysis of a phase 3, randomized, double-blind, placebo-controlled study

 

Guselkumab Q4W

(N = 245)

Guselkumab Q8W

(N = 248)

Pooled Guselkumab

(N = 493)

Age, years

45.9 (11.5)

44.9 (11.9)

45.4 (11.7)

Male sex, n (%)

142 (58%)

129 (52%)

271 (55%)

Race, n (%)

   

 White

 Asian

242 (99%)

3 (1%)

240 (97%)

8 (3%)

482 (98%)

11 (2%)

BMI, kg/m2

 Normal (< 18.5–<25 kg/m2), n (%)

 Overweight (25–<30 kg/m2), n (%)

 Obese (≥ 30 kg/m2), n (%)

29.1 (5.9)

66 (26.9%)

83 (33.9%)

96 (39.2%)

28.7 (6.3)

74 (29.8%)

82 (33.1%)

92 (37.1%)

28.9 (6.1)

140 (28.4%)

165 (33.5%)

188 (38.1%)

PsA duration, years

5.5 (5.9)

5.1 (5.5)

5.3 (5.7)

SJC (0–66)

12.9 (7.8)

11.7 (6.8)

12.3 (7.4)

TJC (0–68)

22.4 (13.5)

19.8 (11.9)

21.1 (12.8)

HAQ-DI score (0–3)

1.2 (0.6)

1.3 (0.6)

1.3 (0.6)

PtGA– arthritis VAS (0–10 cm)

6.4 (1.9)

6.5 (1.9)

6.5 (1.9)

Pt Pain VAS (0–10 cm)

6.2 (2.0)

6.3 (2.0)

6.2 (2.0)

PASI score (0–72)

10.8 (11.7)

9.7 (11.7)

10.2 (11.7)

Enthesitis, n (%)

 LEI score

170 (69%)

3.0 (1.7)

158 (64%)

2.6 (1.5)

328 (67%)

2.8 (1.6)

FACIT-Fatigue score

30.8 (9.6)

29.3 (9.9)

30.0 (9.8)

Medical history of depression, n (%)

4 (1.6%)

4 (1.6%)

8 (1.6%)

Suicidal ideation (eC-SSRS), n (%)*

3 (1.2%)

6 (2.4%)

9 (1.8%)

Medical history of fibromyalgia, n (%)

2 (0.8%)

1 (0.4%)

3 (0.6%)

  1. Data are presented as mean (standard deviation) unless stated otherwise
  2. BMI = body mass index; eC-SSRS = electronic Columbia-Suicidality Severity Rating Scale; FACIT = Functional Assessment of Chronic Illness Therapy; HAQ-DI = Health Assessment Questionnaire-Disability Index; LEI = Leeds enthesitis index; PASI = Psoriasis Area Severity Index; PsA = psoriatic arthritis; Pt = patient; PtGA = patient global assessment; Q4W = every 4 weeks; Q8W = every 8 weeks; SJC = swollen joint count; TJC = tender joint count; VAS = visual analog scale
  3. *Patients with unstable suicidal ideation/behavior who were at risk were excluded from DISCOVER-2