Table 3 Genotype and allele frequencies of TLR9 gene variants in BD and healthy controls
SNP | BD patients N (%) | Healthy controls N (%) | OR (95%CI) | p-value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total | Male | Female | Total | Male | Female | Total | Male | Female | Total | Male | Female | ||
rs187084 | |||||||||||||
Genotypes | AA | 80 (39) | 35 (39.3) | 45 (38.8) | 58 (28) | 25 (25) | 33 (30.8) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
AG | 96 (46.8) | 39 (43.8) | 57 (49.1) | 116 (56) | 52 (52) | 64 (59.8) | 0.6 0.38–0.92 | 0.53 0.27–1.03 | 0.65 0.36–1.15 | 0.02 | 0.063 | 0.14 | |
GG | 29 (14.1) | 15 (16.9) | 14 (12.1) | 33 (15.9) | 23 (23) | 10 (9.3) | 0.63 0.34–1.16 | 0.46 0.2–1.06 | 1.02 0.4–2.5 | 0.14 | 0.07 | 0.95 | |
Alleles | A | 256 (62.4) | 109 (61.2) | 147 (63.4) | 232 (56) | 102 (51) | 130 (60.8) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
G | 154 (37.6) | 69 (38.8) | 85 (36.6) | 182 (44) | 98 (49) | 84 (39.2) | 0.76 0.58–1.01 | 0.66 0.43–0.99 | 0.89 0.61–1.31 | 0.06 | 0.045 | 0.56 | |
Genotype combination | GG | 29 (14.1) | 15 (16.9) | 14 (12.1) | 33 (15.9) | 23 (23) | 10 (9.3) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
AA + AG | 176 (85.9) | 74 (83.1) | 102 (87.9) | 174 (78) | 77 (77) | 97 (90.7) | 1.15 0.67–1.97 | 1.47 0.71–3.04 | 0.75 0.31–1.77 | 0.61 | 0.29 | 0.51 | |
AA | 80 (39) | 35 (39.3) | 45 (49.1) | 58 (28) | 25 (25) | 33 (30.8) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
GG + AG | 125 (61) | 54 (60.7) | 71 (50.9) | 149 (72) | 75 (75) | 74 (69.2) | 0.6 0.4–0.91 | 0.51 0.27–0.95 | 0.7 0.4–1.22 | 0.018 | 0.035 | 0.21 | |
rs352140 | |||||||||||||
Genotypes | CC | 57 (28.7) | 26 (29.2) | 31 (26.7) | 39 (18.8) | 27 (27) | 12 (11.2) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
CT | 100 (48.8) | 40 (44.9) | 60 (51.7) | 129 (62.3) | 48 (48) | 81 (75.7) | 0.53 0.33–0.86 | 0.86 0.4–1.7 | 0.29 0.14–0.60 | 0.01 | 0.68 | 0.001 | |
TT | 48 (23.4) | 23 (25.8) | 25 (21.6) | 39 (18.8) | 25 (25) | 14 (13.1) | 0.84 0.46–1.5 | 0.9 0.44–2.08 | 0.69 0.27–1.75 | 0.57 | 0.9 | 0.44 | |
Alleles | C | 214 (52.2) | 92 (51.7) | 122 (52.6) | 207 (50) | 102 (51) | 105 (49) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
T | 196 (47.8) | 86 (48.3) | 110 (47.4) | 207 (50) | 98 (49) | 109 (51) | 0.9 0.69–1.19 | 0.97 0.65–1.4 | 0.87 0.6–1.26 | 0.53 | 0.89 | 0.46 | |
Genotype combination | CC | 57 (27.8) | 26 (29.2) | 31 (26.7) | 39 (18.8) | 27 (27) | 12 (11.2) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference)) | |||
TT + CT | 148 (72.2) | 63 (70.8) | 85 (73.3) | 168 (81.2) | 73 (73) | 95 (88.8) | 0.6 0.38–0.96 | 0.9 0.47–1.7 | 0.35 0.17–0.72 | 0.032 | 0.73 | 0.004 | |
TT | 48 (23.4) | 23 (25.8) | 25 (21.6) | 39 (18.8) | 25 (25) | 14 (13.1) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||||
CC + CT | 157 (76.6) | 66 (74.2) | 91 (78.4) | 168 (81.2) | 75 (75) | 93 (86.9) | 0.76 0.47–1.22 | 0.96 0.5–1.84 | 0.55 0.27–1.12 | 0.26 | 0.89 | 0.099 | |