Table 4 Association between genotypes and alleles of rs187084 and rs352140 and complications of BD
Total | Male | Female | Total | Male | Female | Total | Male | Female | Total | Male | Female | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
TLR9 rs187084 | ||||||||||||
Oral aphthous | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
AA | 67 (37.8) | 29 (37.2) | 38 (38.4) | 1 (33.3) | 1 (50.0) | 0 (0.0) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
AG | 83 (46.9) | 35 (44.9) | 48 (48.5) | 2 (66.7) | 1 (50.0) | 1 (100) | 0.6 0.05–6.9 | 1.2 0.07–20.1 | 0.4 0.02–10.6 | 0.7 | 0.9 | 0.6 |
GG | 27 (15.3) | 14 (17.9) | 13 (13.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1.2 0.05–30.9 | 1.5 0.06–38.5 | 0.3 0.007–18.5 | 0.9 | 0.8 | 0.6 |
A | 217 (61.3) | 93 (59.6) | 124 (62.6) | 4 (66.7) | 3 (75.5) | 1 (50.0) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
G | 137 (38.7) | 63 (40.4) | 74 (37.4) | 2 (33.3) | 1 (25.0) | 1 (50.0) | 1.3 0.2–6.9 | 2.03 0.2–19.9 | 0.6 0.4–9.7 | 0.8 | 0.6 | 0.7 |
Genital aphthous | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
AA | 34 (32.4) | 11 (25.0) | 23 (37.7) | 32 (47.1) | 17 (53.1) | 15 (41.7) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
AG | 55 (52.4) | 24 (54.5) | 31 (50.8) | 27 (39.7) | 10 (31.3) | 17 (47.2) | 1.9 0.9–3.7 | 3.7 1.3–1.7 | 1.2 0.5–2.9 | 0.6 | 0.01 | 0.7 |
GG | 16 (15.2) | 9 (20.5) | 7 (11.5) | 9 (13.2) | 5 (15.6) | 4 (11.1) | 1.6 0.6–4.3 | 2.8 0.7–10.5 | 1.14 0.3–4.6 | 0.3 | 0.13 | 0.8 |
A | 123 (58.6) | 46 (52.3) | 77 (63.1) | 91 (66.9) | 44 (68.7) | 47 (65.3) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
G | 87 (41.4) | 42 (47.7) | 45 (36.9) | 45 (33.1) | 20 (31.3) | 25 (34.7) | 1.4 0.9–2.2 | 2.0 1.02–3.9 | 1.1 0.6–2.01 | 0.1 | 0.046 | 0.8 |
Skin involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
AA | 32 (37.2) | 16 (34.8) | 16 (40.0) | 34 (38.6) | 13 (41.9) | 21 (36.8) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
AG | 36 (41.9) | 19 (41.3) | 17 (42.5) | 46 (52.3) | 15 (48.4) | 31 (54.4) | 0.8 0.4–1.6 | 1.02 0.4–2.8 | 0.7 0.3–1.7 | 0.6 | 0.9 | 0.5 |
GG | 18 (20.9) | 11 (23.9) | 7 (17.5) | 8 (9.1) | 3 (9.7) | 5 (8.8) | 2.4 0.9–6.3 | 2.9 0.7–12.9 | 1.8 0.5–6.9 | 0.07 | 0.1 | 0.4 |
A | 100 (58.1) | 51 (55.4) | 49 (61.2) | 114 (64.8) | 41 (66.1) | 73 (64.0) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
G | 72 (41.9) | 41 (44.60 | 31 (38.8) | 62 (35.2) | 21 (33.9) | 41 (36.0) | 1.3 0.9–2.04 | 1.6 0.8–3.06 | 1.1 0.6–2.03 | 0.2 | 0.18 | 0.7 |
Eye involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
AA | 28 (41.8) | 13 (41.9) | 15 (41.7) | 36 (40.0) | 15 (42.9) | 21 (38.2) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
AG | 30 (44.8) | 13 (41.9) | 17 (47.2) | 38 (42.2) | 12 (34.3) | 26 (47.3) | 1.01 0.5–2.01 | 1.2 0.4–3.7 | 0.9 0.4–2.2 | 0.9 | 0.7 | 0.8 |
GG | 9 (13.4) | 5 (16.1) | 4 (11.1) | 16 (17.8) | 8 (22.9) | 8 (14.5) | 0.7 0.3–1.9 | 0.7 0.2–2.8 | 0.7 0.2–2.7 | 0.5 | 0.6 | 0.6 |
A | 86 (64.2) | 39 (62.9) | 47 (65.3) | 110 (61.1) | 42 (60.0) | 68 (61.8) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
G | 48 (35.8) | 23 (37.1) | 25 (34.7) | 70 ((38.9) | 28 (40.0) | 42 (38.2) | 0.9 0.6–1.4 | 0.9 0.4–1.8 | 0.9 0.5–1.6 | 0.6 | 0.7 | 0.6 |
joint involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
AA | 44 (39.6) | 15 (34.1) | 29 (43.3) | 25 (36.2) | 15 (42.9) | 10 (29.4) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
AG | 51 (45.9) | 21 (47.7) | 30 (44.8) | 33 (47.8) | 14 (40.0) | 19 (55.9) | 0.9 0.4–1.7 | 1.5 0.6–4.01 | 0.5 0.2–1.4 | 0.7 | 0.4 | 0.2 |
GG | 16 (14.4) | 8 (18.2) | 8 (11.9) | 11 (15.9) | 6 (17.1) | 5 (14.7) | 0.8 0.3–2.06 | 1.3 0.4–4.8 | 0.6 0.1–2.1 | 0.7 | 0.6 | 0.4 |
A | 139 (62.6) | 51 (57.9) | 88 (65.7) | 83 (60.1) | 44 (62.8) | 39 (57.3) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
G | 83 (37.4) | 37 (42.1) | 46 (34.3) | 55 (39.9) | 26 (37.2) | 29 (42.7) | 0.9 0.6–1.4 | 0.2 0.6–2.3 | 0.7 0.4–1.3 | 0.6 | 0.5 | 0.2 |
Neural involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
AA | 21 (39.6) | 9 (39.1) | 12 (40.0) | 46 (38.0) | 20 (36.4) | 26 (39.4) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
AG | 21 (39.6) | 9 (39.1) | 12 (40.0) | 60 (49.6) | 27 (49.1) | 33 (50.0) | 0.8 0.4–1.6 | 0.7 0.2–2.2 | 0.8 0.3–2.03 | 0.5 | 0.6 | 0.6 |
GG | 11 (20.8) | 5 (21.7) | 6 (20.0) | 15 (12.4) | 8 (14.5) | 7 (10.6) | 1.6 0.6–4.1 | 0.4 0.3–5.4 | 1.8 0.5–6.7 | 0.3 | 0.6 | 0.3 |
A | 63 (59.4) | 27 (58.7) | 36 (60.0) | 152 (62.8) | 47 (52.2) | 85 (64.4) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
G | 43 (40.6) | 19 (41.3) | 24 (40.0) | 90 (37.2) | 43 (47.8) | 47 (35.6) | 1.1 0.7–1.8 | 0.8 0.4–1.6 | 1.2 0.7–2.2 | 0.6 | 0.5 | 0.6 |
Vascular involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
AA | 5 (38.5) | 3 (30.0) | 2 (66.70 | 63 (38.7) | 27 (39.1) | 36 (38.3) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
AG | 5 (38.5) | 4 (40.0) | 1 (33.3) | 78 (47.9) | 32 (46.4) | 46 (48.9) | 0.8 0.2–2.9 | 1.1 0.2–5.5 | 0.4 0.03–4.5 | 0.7 | 0.9 | 0.4 |
GG | 3 (23.1) | 3 (30.0) | 0 (0.0) | 22 (13.5) | 10 (14.5) | 12 (12.8) | 1.7 0.4–7.8 | 2.7 0.5–15.6 | 0.6 0.03–13.01 | 0.5 | 0.3 | 0.7 |
A | 15 (57.7) | 10 (50.0) | 5 (83.3) | 204 (62.6) | 86 (62.3) | 118 (62.8) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
G | 11 (42.3) | 10 (50.0) | 1 (16.7) | 122 (37.4) | 52 (37.7) | 70 (37.2) | 1.2 0.5–2.7 | 1.6 0.6–4.2 | 0.3 0.04–2.9 | 0.6 | 0.3 | 0.3 |
Cardiac involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
AA | 3 (27.3) | 1 (14.3) | 2 (50.0) | 63 (39.1) | 34 (37.8) | 29 (40.8) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
AG | 5 (45.5) | 4 (57.1) | 1 (25.0) | 76 (47.2) | 45 (50.0) | 31 (43.7) | 1.4 0.3-6.0 | 3.02 0.3–28.3 | 0.5 0.04–5.4 | 0.7 | 0.3 | 0.5 |
GG | 3 (27.3) | 2 (28.6) | 1 (25.0) | 22 (13.7) | 11 (12.2) | 11 (15.5) | 0.9 0.5–15.2 | 6.2 0.5–74.9 | 1.3 0.1–16.0 | 0.2 | 0.1 | 0.8 |
A | 11 (50.0) | 6 (42.8) | 5 (62.5) | 202 (62.7) | 113 (62.8) | 89 (62.7) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
G | 11 (50.0) | 8 (57.2) | 3 (37.5) | 120 (37.3) | 67 (37.2) | 53 (37.3) | 1.7 0.7-4.0 | 2.2 0.7–6.8 | 1.0 0.2–4.4 | 0.2 | 0.15 | 0.9 |
Lung involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
AA | 1 (16.7) | 0 (0.0) | 1 (33.3) | 46 (36.5) | 24 (36.9) | 22 (36.1) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
AG | 4 (66.7) | 3 (100) | 1 (33.3) | 61 (48.4) | 30 (46.2) | 31 (50.8) | 3.01 0.3–27.9 | 5.6 0.3-111.1 | 0.7 0.04–11.9 | 0.3 | 0.3 | 0.8 |
GG | 1 (16.7) | 0 (0.0) | 1 (33.3) | 19 (15.1) | 11 (16.9) | 8 (13.1) | 2.4 0.1–40.7 | 2.1 0.04–114.2 | 2.7 0.15–49.4 | 0.5 | 0.7 | 0.5 |
A | 6 (50.0) | 3 (50.0) | 3 (50.0) | 153 (60.7) | 78 (60.0) | 75 (61.5) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
G | 6 (50.0) | 3 (50.0) | 3 (50.0) | 99 (39.3) | 52 (40.0) | 47 (38.5) | 1.5 0.5–4.9 | 1.5 0.3–7.7 | 1.6 0.3–8.2 | 0.5 | 0.6 | 0.6 |
Renal involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
AA | 8 (44.4) | 3 (42.9) | 5 (45.5) | 59 (37.1) | 25 (35.2) | 34 (38.6) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
AG | 8 (44.4) | 3 (42.9) | 5 (45.5) | 76 (47.8) | 33 (46.5) | 43 (48.9) | 0.8 0.3–2.2 | 0.7 0.14–4.1 | 0.8 0.2–2.9 | 0.6 | 0.7 | 0.7 |
GG | 2 (11.1) | 1 (14.3) | 1 (9.1) | 24 (15.1) | 13 (18.3) | 11 (12.5) | 0.6 0.1–3.1 | 0.6 0.1–6.8 | 0.6 0.1–5.9 | 0.6 | 0.7 | 0.7 |
A | 24 (66.7) | 9 (64.3) | 15 (68.2) | 194 (61.0) | 83 (58.4) | 111 (63.1) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
G | 12 (33.3) | 5 (35.7) | 7 (31.8) | 124 (39.0) | 59 (41.6) | 65 (36.9) | 0.8 0.4–1.6 | 0.8 0.2–2.4 | 0.8 0.3–2.06 | 0.5 | 0.7 | 0.6 |
Gastrointestinal involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
AA | 7 (41.2) | 4 (66.7) | 3 (27.3) | 57 (38.8) | 24 (34.8) | 33 (42.3) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
AG | 6 (35.3) | 1 (16.7) | 5 (45.5) | 70 (47.6) | 33 (47.8) | 37 (47.4) | 0.7 0.2–2.2 | 0.2 0.02–1.7 | 1.5 0.3–6.7 | 0.5 | 0.1 | 0.6 |
GG | 4 (23.5) | 1 (16.7) | 3 (27.3) | 20 (13.6) | 12 (17.4) | 8 (10.3) | 1.6 0.4–6.1 | 0.5 0.05–4.9 | 4.1 0.7–24.4 | 0.5 | 0.6 | 0.1 |
A | 20 (58.8) | 9 (75.0) | 11 (50.0) | 184 (62.6) | 81 (58.7) | 103 (66.0) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
G | 14 (41.2) | 3 (25.0) | 11 (50.0) | 110 (37.4) | 57 (41.3) | 53 (34.0) | 1.2 0.6–2.4 | 0.5 0.1–1.8 | 1.9 0.8–4.8 | 0.7 | 0.3 | 0.1 |
TLR9rs352140 | ||||||||||||
Oral aphthous | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
TT | 44 (24.9) | 21 (26.9) | 23 (23.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
CT | 84 (47.5) | 36 (46.2) | 48 (48.5) | 2 (66.7) | 1 (50.0) | 1 (100) | 0.4 0.02–8.1 | 0.6 0.02–14.5 | 0.7 0.03–17.5 | 0.5 | 0.7 | 0.8 |
CC | 49 (27.7) | 21 (26.9) | 28 (28.3) | 1 (33.3) | 1 (50.0) | 0 (0.0) | 0.4 0.01–9.3 | 0.3 0.01–8.6 | 1.2 0.02–63.5 | 0.5 | 0.5 | 0.9 |
T | 172 (48.6) | 78 (50.0) | 94 (47.5) | 2 (33.3) | 1 (25.0) | 1 (50.0) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
C | 182 (51.4) | 78 (50.0) | 104 (52.5) | 4 (66.7) | 3 (75.0) | 1 (50.0) | 0.5 0.9–2.9 | 0.3 0.03–3.3 | 1.1 0.07–17.9 | 0.5 | 0.3 | 0.9 |
Genital aphthous | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
TT | 24 (22.9) | 12 (27.3) | 12 (19.7) | 16 (23.5) | 8 (25.0) | 8 (22.2) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
CT | 53 (50.5) | 22 (50.0) | 31 (50.8) | 31 (45.6) | 13 (40.6) | 18 (50.0) | 1.1 0.5–2.5 | 1.12 0.4–3.5 | 1.15 0.4–3.3 | 0.7 | 0.8 | 0.8 |
CC | 28 (26.7) | 10 (22.7) | 18 (29.5) | 21 (30.9) | 11 (34.4) | 10 (27.8) | 0.9 0.4–2.1 | 0.6 0.2–2.1 | 1.2 0.4–3.9 | 0.8 | 0.4 | 0.8 |
T | 101 (48.1) | 46 (52.3) | 55 (45.1) | 63 (46.3) | 29 (45.3) | 34 (47.2) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
C | 109 (51.9) | 42 (47.7) | 67 (54.9) | 73 (53.7) | 35 (54.7) | 38 (52.8) | 0.9 0.6–1.4 | 0.7 0.4–1.4 | 1.1 0.6–1.9 | 0.7 | 0.4 | 0.8 |
Skin involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
TT | 25 (29.1) | 14 (30.4) | 11 (27.5) | 18 (20.5) | 7 (22.6) | 11 (19.3) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
CT | 34 (39.5) | 18 (39.1) | 16 (40.0) | 49 (55.7) | 17 (54.8) | 32 (56.1) | 0.5 0.2–1.05 | 0.5 0.2–1.6 | 0.5 0.2–0.4 | 0.07 | 0.3 | 0.2 |
CC | 27 (31.4) | 14 (30.4) | 13 (32.5) | 21 (23.9) | 7 (22.6) | 14 (24.6) | 0.9 0.4–2.1 | 1.0 0.3–3.06 | 0.9 0.3–2.9 | 0.8 | 1.0 | 0.9 |
T | 84 (48.8) | 46 (50.0) | 38 (47.5) | 85 (48.3) | 31 (50.0) | 54 (47.4) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
C | 88 (51.2) | 46 (50.0) | 42 (52.5) | 91 (51.7) | 31 (50.0) | 60 (52.6) | 0.9 0.6–1.5 | 1.0 0.5–1.9 | 0.9 0.6–1.8 | 0.9 | 1.0 | 0.9 |
Eye involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
TT | 13 (19.4) | 7 (22.6) | 6 (16.7) | 24 (26.7) | 10 (28.6) | 14 (25.5) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
CT | 31 (46.3) | 15 (48.4) | 16 (44.4) | 44 (48.9) | 15 (42.9) | 29 (52.7) | 1.3 0.6–2.9 | 1.4 0.4–4.7 | 1.3 0.4-4.0 | 0.5 | 0.6 | 0.7 |
CC | 23 (34.3) | 9 (29.0) | 14 (38.9) | 22 (24.4) | 10 (28.6) | 12 (21.8) | 1.9 0.8–4.7 | 1.3 0.3–4.8 | 2.7 0.8–9.3 | 0.1 | 0.7 | 0.1 |
T | 57 (42.5) | 29 (46.8) | 28 (38.9) | 92 (51.1) | 35 (50.0) | 57 (51.8) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
C | 77 (57.5) | 33 (53.2) | 44 (61.1) | 88 (48.9) | 35 (50.0) | 53 (48.2) | 1.4 0.9–2.2 | 1.3 0.6–2.2 | 1.7 0.9–3.1 | 0.1 | 0.7 | 0.09 |
Joint involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
TT | 24 (21.6) | 12 (27.3) | 12 (17.9) | 19 (27.5) | 8 (22.9) | 11 (32.4) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
CT | 56 (50.5) | 19 (43.2) | 37 (55.2) | 31 (44.9) | 18 (51.4) | 13 (38.2) | 1.4 0.7–3.01 | 0.7 0.2–2.1 | 2.6 0.9–7.3 | 0.3 | 0.5 | 0.07 |
CC | 31 (27.9) | 13 (29.5) | 18 (26.9) | 19 (27.5) | 9 (25.7) | 10 (29.4) | 1.3 0.6–2.9 | 0.9 0.3–3.3 | 1.6 0.5–5.1 | 0.5 | 0.9 | 0.4 |
T | 104 (46.8) | 43 (48.9) | 61 (45.5) | 69 (50.0) | 34 (48.6) | 35 (48.5) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
C | 118 (53.2) | 45 (51.1) | 73 (54.5) | 69 (50.0) | 36 (51.4) | 33 (51.5) | 1.1 0.7–1.7 | 0.9 0.5–1.8 | 1.3 0.7–2.3 | 0.6 | 0.9 | 0.4 |
Neural involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
TT | 15 (28.3) | 8 (34.8) | 7 (23.3) | 29 (24.0) | 13 (23.6) | 16 (24.2) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
CT | 24 (45.3) | 9 (39.1) | 15 (50.0) | 60 (49.6) | 27 (49.1) | 33 (50.0) | 0.8 0.3–1.7 | 0.54 0.2–1.7 | 1.04 0.3–3.05 | 0.5 | 0.3 | 0.9 |
CC | 14 (26.4) | 6 (26.1) | 8 (26.7) | 32 (26.4) | 15 (27.3) | 17 (25.8) | 0.8 0.3-2.0 | 0.6 0.2–2.4 | 1.07 0.3–3.6 | 0.7 | 0.5 | 0.9 |
T | 54 (50.9) | 25 (54.3) | 29 (48.3) | 118 (48.8) | 53 (48.1) | 65 (49.2) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
C | 52 (49.1) | 21 (45.7) | 31 (51.7) | 124 (51.2) | 57 (51.9) | 67 (50.8) | 0.9 0.6–1.4 | 0.8 0.4–1.6 | 1.04 0.6–1.9 | 0.7 | 0.5 | 0.9 |
Vascular involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
TT | 4 (30.8) | 4 (40.0) | 0 (0.0) | 38 (23.3) | 17 (24.6) | 21 (22.3) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
CT | 3 (23.1) | 2 (20.0) | 1 (33.3) | 83 (50.9) | 35 (50.7) | 48 (51.1) | 0.3 0.07–1.6 | 0.2 0.04–1.4 | 1.3 0.05–33.9 | 0.2 | 0.12 | 0.9 |
CC | 6 (46.2) | 4 (40.0) | 2 (66.7) | 42 (25.8) | 17 (24.6) | 25 (26.6) | 1.3 0.3–5.2 | 1.0 0.2–4.7 | 4.2 0.2–92.7 | 0.6 | 1.0 | 0.4 |
T | 11 (42.3) | 10 (50.0) | 1 (16.7) | 159 (48.8) | 69 (50.0) | 90 (47.9) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
C | 15 (57.7) | 10 (50.0) | 5 (83.7) | 167 (51.2) | 69 (50.0) | 98 (52.1) | 1.3 0.6–2.9 | 1.0 0.4–2.6 | 4.6 0.5-40.06 | 0.5 | 1.0 | 0.17 |
Cardiac involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
TT | 3 (27.3) | 2 (28.6) | 1 (25.0) | 39 (24.2) | 19 (26.8) | 20 (22.2) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
CT | 5 (45.5) | 3 (42.9) | 2 (50.0) | 77 (47.8) | 33 (46.5) | 44 (48.9) | 0.8 0.2–3.7 | 0.9 0.1–5.6 | 0.9 0.08–10.6 | 0.8 | 0.9 | 0.9 |
CC | 3 (27.3) | 2 (28.6) | 1 (25.0) | 45 (28.0) | 19 (26.8) | 26 (28.9) | 0.9 0.2–4.5 | 1.0 0.1–7.8 | 0.8 0.04–13.1 | 0.9 | 1.0 | 0.8 |
T | 11 (50.0) | 7 (50.0) | 4 (50.0) | 155 (48.1) | 71 (50.0) | 84 (46.7) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
C | 11 (50.0) | 7 (50.0) | 4 (50.0) | 167 (51.9) | 71 (50.0) | 96 (53.3) | 0.9 0.4–2.2 | 1.0 0.3–2.9 | 0.9 0.2–3.6 | 0.9 | 1.0 | 0.8 |
Lung involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
TT | 1 (16.7) | 0 (0.0) | 1 (33.3) | 35 (27.8) | 19 (29.2) | 16 (26.20 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
CT | 5 (83.3) | 3 (100) | 2 (66.7) | 55 (43.7) | 27 (41.5) | 28 (45.9) | 3.2 0.3–28.4 | 4.9 0.2-101.7 | 1.1 0.09–13.6 | 0.3 | 0.3 | 0.9 |
CC | 0 (0.0) | 0 (0.0) | 0 (0.0) | 36 (28.6) | 19 (29.2) | 17 (27.9) | 0.3 0.01–8.2 | 1.0 0.02–52.9 | 0.3 0.01–8.3 | 0.5 | 1.0 | 0.5 |
T | 7 (58.3) | 3 (50.0) | 4 (66.7) | 125 (49.6) | 65 (50.0) | 60 (49.2) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
C | 5 (41.7) | 3 (50.0) | 2 (33.3) | 127 (50.4) | 65 (50.0) | 62 (50.8) | 0.7 0.2–2.3 | 1.0 0.2–5.1 | 0.5 0.08–2.7 | 0.5 | 1.0 | 0.4 |
Renal involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
TT | 3 (16.7) | 2 (28.6) | 1 (9.1) | 40 (25.2) | 19 (26.8) | 21 (23.9) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
CT | 9 (50.0) | 4 (57.1) | 5 (45.5) | 76 (47.8) | 32 (45.1) | 44 (50.0) | 1.6 0.4–6.2 | 1.2 0.2–7.1 | 2.4 0.3–21.7 | 0.5 | 0.8 | 0.4 |
CC | 6 (33.3) | 1 (14.3) | 5 (45.5) | 43 (27.0) | 20 (28.2) | 23 (26.1) | 1.9 0.4–7.9 | 0.47 0.04–5.7 | 4.6 0.5–42.3 | 0.4 | 0.6 | 0.2 |
T | 15 (41.7) | 8 (57.1) | 7 (31.8) | 156 (49.0) | 70 (49.3) | 86 (48.9) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
C | 21 (58.3) | 6 (42.9) | 15 (68.2) | 162 (51.0) | 72 (50.7) | 90 (51.1) | 0.3 0.7–2.7 | 0.7 0.2–2.2 | 2.05 0.8–5.3 | 0.4 | 0.6 | 0.14 |
Gastrointestinal involvement | ||||||||||||
Positive | Negative | OR (95% CI) | p-value | |||||||||
TT | 7 (41.2) | 2 (33.3) | 5 (45.5) | 34 (23.1) | 19 (27.5) | 15 (19.2) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
CT | 6 (35.3) | 2 (33.3) | 4 (36.4) | 73 (49.7) | 32 (46.4) | 41 (52.6) | 0.4 0.12–1.3 | 0.6 0.08–4.6 | 3.4 0.8–14.4 | 0.1 | 0.6 | 0.11 |
CC | 4 (23.5) | 2 (33.3) | 2 (18.2) | 40 (27.2) | 18 (26.1) | 22 (28.2) | 0.5 0.13–1.8 | 1.06 0.13–8.3 | 0.3 0.05–1.6 | 0.3 | 0.9 | 0.15 |
T | 20 (58.8) | 6 (50.0) | 14 (63.6) | 141 (47.9) | 70 (50.7) | 71 (45.5) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
C | 14 (41.2) | 6 (50.0) | 8 (36.4) | 153 (52.1) | 68 (49.3) | 85 (54.5) | 0.6 0.3–1.3 | 1.03 0.3–3.3 | 2.1 0.83–5.3 | 0.2 | 0.9 | 0.17 |