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Table 3 Minimal clinically important difference in change from baseline to Week 24 by MDA responder (R) or non-responder (NR) status

From: Achieving minimal disease activity in psoriatic arthritis predicts meaningful improvements in patients’ health-related quality of life and productivity

Achieved MCID Improvement MDA-R (n = 152) MDA-NR (n = 322) P-Value Ɣ-Value (ASE)a Odds Ratio (95% CIs)
SF-36 Domains
 Physical functioning
  Yes 124 (81.6%) 182 (56.5%) <.001 3.41
  No 28 (18.4%) 140 (43.5%) .55 (.083) (2.14, 5.43)
 Role physical
  Yes 124 (81.6%) 175 (54.3%) <.001 3.72
  No 28 (18.4%) 147 (45.7%) .58 (.079) (2.34, 5.92)
 Bodily pain
  Yes 130 (85.5%) 188 (58.4%) <.001 4.21
  No 22 (14.5%) 134 (41.6%) .62 (.080) (2.55, 6.97)
 General health
  Yes 121 (79.6%) 166 (51.6%) <.001 3.67
  No 31 (20.4%) 156 (48.4%) .57 (.077) (2.34, 5.76)
 Vitality
  Yes 118 (77.6%) 184 (57.1%) <.001 2.60
  No 34 (22.4%) 138 (42.9%) .44 (.090) (1.68, 4.04)
 Social functioning
  Yes 95 (62.5%) 149 (46.3%) <.001 1.94
  No 57 (37.5%) 173 (53.7%) .32 (.090) (1.30, 2.87)
 Role emotional
  Yes 66 (43.4%) 143 (44.4%) .840 .96
  No 86 (56.6%) 179 (55.6%) −.02 (.099) (0.65, 1.42)
 Mental health
  Yes 90 (59.2%) 166 (51.6%) .118 1.36
  No 62 (40.8%) 156 (48.4%) .15 (.097) (0.92, 2.02)
 SF-36 PCS
  Yes 130 (85.5%) 157 (48.8%) <.001 6.21
  No 22 (14.5%) 165 (51.2%) .72 (.061) (3.76, 10.26)
 SF-36 MCS
  Yes 80 (52.6%) 160 (49.7%) .550 1.13
  No 72 (47.4%) 162 (50.3%) .06 (.098) (0.76, 1.66)
 EQ-5D-5 L HSI
  Yes 117 (77.0%) 152 (47.2%) <.001 3.74
  No 35 (23.0%) 170 (52.8%) .58 (.074) (2.42, 5.78)
 EQ-5D VAS
  Yes 113 (74.3%) 130 (40.4%) <.001 4.28
  No 39 (25.7%) 192 (59.6%) .62 (.067) (2.79, 6.56)
  1. aƔ-values near 1 indicate a strong association between clinical response and MDA. Abbreviations: ASE = asymptotic standard error, CIs = confidence intervals, EQ-5D-5 L = European Quality of Life 5 Dimension 5 Level Health Questionnaire, HSI = Health State Index, MCID = minimal clinically important difference, MCS = mental component summary, MDA = minimal disease activity, PCS = physical component summary, SF-36 = 36-Item Short Form Health Survey, VAS = visual analog scale