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  1. Educational attainment is moderately heritable and inversely associated with the risk of rheumatoid arthritis. However, the causality from educational attainment on rheumatoid arthritis remained unknown. Here,...

    Authors: Guiwu Huang, Jiahao Cai, Wenchang Li, Yanlin Zhong, Weiming Liao and Peihui Wu

    Citation: BMC Rheumatology 2021 5:47

    Content type: Research

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  2. Inflammatory arthritis (IA) patients have been identified as at greater risk of severe illness from COVID-19. It is likely that lockdown restrictions (enforced by the UK government in response to the COVID-19 ...

    Authors: Emma Caton, Hema Chaplin, Lewis Carpenter, Melissa Sweeney, Hsiu Yen Tung, Savia de Souza, James Galloway, Elena Nikiphorou and Sam Norton

    Citation: BMC Rheumatology 2021 5:58

    Content type: Research

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  3. We describe Raynauds phenomenon (RP), potential very early diagnosis of systemic sclerosis (VEDOSS), and systemic sclerosis (SSc) in Veterans deployed in support of Post-9/11 operations. We sought to describe ...

    Authors: Tracy M. Frech, Maureen A. Murtaugh, Megan Amuan and Mary Jo Pugh

    Citation: BMC Rheumatology 2021 5:42

    Content type: Research article

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  4. Galactosialidosis (GS) is a rare inherited lysosomal storage disorder (LSD) which is characterized by a defect in the lysosomal glycoprotein catabolism. We report, for the first time, the case of a child affec...

    Authors: F. Verkuil, A. M. Bosch, P. A. A. Struijs, R. Hemke and J. M. van den Berg

    Citation: BMC Rheumatology 2021 5:41

    Content type: Case report

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  5. This study aimed to investigate the hospitalisation rates and the reasons for hospitalisation in patients with polymyalgia rheumatica (PMR). Furthermore, it aimed to clarify the impact of a newly established F...

    Authors: Stavros Chrysidis, Philip Rask Lage-Hansen, Nikoletta Svendsen and Andreas P. Diamantopoulos

    Citation: BMC Rheumatology 2021 5:37

    Content type: Research

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  6. Ocular manifestations are common in systemic lupus erythematosus (SLE). Retinopathy has previously been linked to disease severity and might have a significant impact on the patient’s quality of life and has a...

    Authors: Hamidreza Bashiri, Nooshin Karimi, Shayan Mostafaei, Azarakhsh Baghdadi, Mohammad Nejadhosseinian and Seyedeh Tahereh Faezi

    Citation: BMC Rheumatology 2021 5:34

    Content type: Research

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  7. Patients with non-radiographic axial spondyloarthritis experience negative impacts on sleep, work productivity, and activity impairment. Ixekizumab, a monoclonal antibody selectively targeting interleukin-17A,...

    Authors: Atul Deodhar, Philip Mease, Helena Marzo-Ortega, Theresa Hunter, David Sandoval, Andris Kronbergs, Steven Lauzon, Ann Leung and Victoria Navarro-Compán

    Citation: BMC Rheumatology 2021 5:50

    Content type: Research

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  8. This analysis assessed improvements in patients with radiographic axial spondyloarthritis (r-axSpA) treated with ixekizumab in the Assessment of Spondyloarthritis International Society (ASAS) treatment respons...

    Authors: Atul A. Deodhar, Philip J. Mease, Proton Rahman, Victoria Navarro-Compán, Vibeke Strand, Theresa Hunter, Rebecca Bolce, Luis Leon, Steve Lauzon and Helena Marzo-Ortega

    Citation: BMC Rheumatology 2021 5:35

    Content type: Research

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  9. Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti-neutrophil antibody (ANCA)-associated necrotizing vasculitis, which predominantly affects small to medium vessels, and is associated with asthma ...

    Authors: Ken-ei Sada, Atsushi Miyauchi, Daisuke Hashimoto, Riku Ino, Shigeru Nojima, Shingo Yamanaka and Masafumi Kawamura

    Citation: BMC Rheumatology 2021 5:28

    Content type: Case report

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  10. Patients with axial spondyloarthritis (axSpA) may experience spinal stiffness and pain, leading to reduced physical function and quality of life. Despite the benefits of physical activity (PA) and exercise, pr...

    Authors: Jie Kie Phang, Andrew Yu Keat Khor, Yu Heng Kwan, Chin Teck Ng and Warren Fong

    Citation: BMC Rheumatology 2021 5:38

    Content type: Research

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  11. Cardiovascular diseases (CVDs) are the leading cause of death in patients with rheumatoid arthritis (RA). Coronary artery calcium (CAC) score quantifies the severity of atherosclerosis. We estimated CVD risk u...

    Authors: Se Hee Kim, Sang-Heon Lee, Hae-Rim Kim and Hong Ki Min

    Citation: BMC Rheumatology 2021 5:39

    Content type: Research

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  12. Elevated serum urate (SU) concentration is the central risk factor for the development of gout. The aim of this study was to examine the incidence of gout in people with low and normal SU levels (< 7.00 mg/dL).

    Authors: Philip C. Robinson, Christopher Frampton, Amanda Phipps-Green, Tuhina Neogi, Lisa Stamp, William Taylor, Tony R. Merriman and Nicola Dalbeth

    Citation: BMC Rheumatology 2021 5:33

    Content type: Research

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  13. The aims of our study were two-fold. Firstly, to determine if there is an association between gout and OSA in a representative Australian adult population. Secondly, to explore associations between gout and pa...

    Authors: Julia New-Tolley, Amy C. Reynolds, Sarah L. Appleton, Tiffany K. Gill, Susan Lester, Robert J. Adams and Catherine L. Hill

    Citation: BMC Rheumatology 2021 5:30

    Content type: Research

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  14. Studies suggest an increased prevalence of cognitive impairment (CI) among people with rheumatoid arthritis (RA). However, most prior studies have used convenience samples which are subject to selection biases...

    Authors: Michael J. Booth, Mary R. Janevic, Lindsay C. Kobayashi, Daniel J. Clauw and John D. Piette

    Citation: BMC Rheumatology 2021 5:24

    Content type: Research

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  15. Inflammation of patients joints with severe disease activity of rheumatoid arthritis (RA) has already been visualized and quantified by 2-[18F]fluoro-2-deoxy-D-glucose positron emission computed tomography ([18F]...

    Authors: Charline Rinkin, Pacôme Fosse, Olivier Malaise, Nathalie Chapelier, Jil Horrion, Laurence Seidel, Adelin Albert, Roland Hustinx and Michel G. Malaise

    Citation: BMC Rheumatology 2021 5:31

    Content type: Research article

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  16. Vasculitides comprise a group of rare diseases which affect less than 5 in 10.000 individuals. Most types of vasculitis can become organ- and life-threatening and are characterized by chronicity, high morbidit...

    Authors: Christof Iking-Konert, Pia Wallmeier, Sabrina Arnold, Sabine Adler, Kirsten de Groot, Bernhard Hellmich, Bimba F. Hoyer, Konstanze Holl-Ulrich, Gabriele Ihorst, Margit Kaufmann, Ina Kötter, Ulf Müller-Ladner, T. Magnus, Jürgen Rech, Fabian Schubach, Hendrik Schulze-Koops…

    Citation: BMC Rheumatology 2021 5:40

    Content type: Study protocol

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  17. Risk of myocardial infarction (MI) is elevated in ankylosing spondylitis and psoriatic arthritis (AS/PsA) compared to the general population. We evaluated the risk of MI related to the use of tumor necrosis fa...

    Authors: Rachael Stovall, Christine Peloquin, David Felson, Tuhina Neogi and Maureen Dubreuil

    Citation: BMC Rheumatology 2021 5:36

    Content type: Research

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  18. Anti-synthetase syndrome is the collection of myositis and/or interstitial lung disease with the presence of various antibodies directed against an aminoacyl transfer RNA synthetase. Anti Jo − 1 antibody is th...

    Authors: C. T. Rosa, A. S. Thilakarathne, L. A. Senevirathne, A. Wijeyeratna and D. Munidasa

    Citation: BMC Rheumatology 2021 5:25

    Content type: Case report

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  19. Our knowledge of immune-mediated inflammatory disease (IMID) aetiology and pathogenesis has improved greatly over recent years, however, very little is known of the factors that trigger disease relapses (flare...

    Authors: Fiona Rayner, Amy E. Anderson, Kenneth F. Baker, Christopher D. Buckley, Bernard Dyke, Sally Fenton, Andrew Filer, Carl S. Goodyear, Catharien M. U. Hilkens, Shaun Hiu, Sean Kerrigan, Mariola Kurowska-Stolarska, Fiona Matthews, Iain McInnes, Wan-Fai Ng, Arthur G. Pratt…

    Citation: BMC Rheumatology 2021 5:22

    Content type: Study protocol

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  20. Research on adherence interventions in rheumatology is limited by methodological issues, particularly heterogeneous outcomes. We aimed to describe researchers’ experiences with conducting interventional studie...

    Authors: Shahrzad Salmasi, Ayano Kelly, Susan J. Bartlett, Maarten de Wit, Lyn March, Allison Tong, Peter Tugwell, Kathleen Tymms, Suzanne Verstappen and Mary A. De Vera

    Citation: BMC Rheumatology 2021 5:26

    Content type: Research article

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  21. Despite progress that has been made in the treatment of many immune-mediated inflammatory diseases (IMIDs), there remains a need for improved treatments. Randomised controlled trials (RCTs) provide the highest...

    Authors: Michael J. Grayling, Theophile Bigirumurame, Svetlana Cherlin, Luke Ouma, Haiyan Zheng and James M. S. Wason

    Citation: BMC Rheumatology 2021 5:21

    Content type: Research article

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  22. Pain and fatigue are persistent problems in people with rheumatoid arthritis. Central sensitisation (CS) may contribute to pain and fatigue, even when treatment has controlled inflammatory disease. This study ...

    Authors: Onosi S. Ifesemen, Daniel F. McWilliams, Eamonn Ferguson, Richard Wakefield, Kehinde Akin-Akinyosoye, Deborah Wilson, Dorothy Platts, Susan Ledbury and David A. Walsh

    Citation: BMC Rheumatology 2021 5:23

    Content type: Study protocol

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  23. Patients with Systemic Lupus Erythematosus (SLE) often experience pain and other symptoms that negatively impact quality of life. Interventions that enhance the use of behavioral and cognitive coping strategie...

    Authors: Kelli D. Allen, Tyler Beauchamp, Christine Rini, Francis J. Keefe, Kim L. Bennell, Rebecca J. Cleveland, Kimberlea Grimm, Katie Huffman, David G. Hu, Andres Santana, Shruti Saxena Beem, Julie Walker and Saira Z. Sheikh

    Citation: BMC Rheumatology 2021 5:20

    Content type: Research article

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  24. Neuropsychiatric manifestations occur in up to 75% of adult systemic lupus erythematosus (SLE) patients and are one of the major causes of death in SLE patients. Cognitive dysfunction is a typical clinical fea...

    Authors: Li Lu, Wei Kong, Kangxing Zhou, Jinglei Chen, Yayi Hou, Huan Dou and Jun Liang

    Citation: BMC Rheumatology 2021 5:18

    Content type: Research article

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  25. Chronic Recurrent Multifocal Osteomyelitis (CRMO) is a condition characterized by sterile bone inflammation, usually occurring in childhood. Although the etiology remains unclear, this condition has been assoc...

    Authors: Hon Yan Ng, Orlee R. Guttman and Lori B. Tucker

    Citation: BMC Rheumatology 2021 5:16

    Content type: Case report

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  26. Polyarteritis nodosa is a type of vasculitis affecting medium- and small-sized arteries that has been associated with hepatitis B but does not have an established relationship with autoimmune hepatitis. Here w...

    Authors: Freda Kennedy, Rachel Kapelow, Bilge D. Kalyon, Nitzan C. Roth, Arvind Rishi and Maria-Louise Barilla-LaBarca

    Citation: BMC Rheumatology 2021 5:17

    Content type: Case report

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  27. Psoriatic arthritis (PsA) presents a unique clinical challenge. Affecting joints, skin, nails, and other organs, it is associated with various comorbidities and has a significant impact on quality of life, soc...

    Authors: Gareth T. Jones, Gary J. Macfarlane, Karen Forrest Keenan, Paul McNamee, Aileen R. Neilson, Stefan Siebert, A. David Burden, Lesley Kay and Philip S. Helliwell

    Citation: BMC Rheumatology 2021 5:19

    Content type: Study protocol

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  28. Fibromyalgia is characterized by chronic widespread pain, and more than half of patients with fibromyalgia report that weather-related variables aggravate their symptoms. However, the differences in actual sym...

    Authors: Kazuhiro Hayashi, Kenji Miki, Noriyuki Hayashi, Ryota Hashimoto and Masao Yukioka

    Citation: BMC Rheumatology 2021 5:14

    Content type: Research article

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  29. The self-reported Health Assessment Questionnaire (HAQ) is specifically designed to assess disability in arthritic patients. In many studies women report higher functional disability than men. The reasons for ...

    Authors: Sidona-Valentina Bala, Maria L. E. Andersson, Kristina Forslind, Björn Svensson and Ingiäld Hafström

    Citation: BMC Rheumatology 2021 5:13

    Content type: Research article

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  30. Adult onset Still’s disease (AOSD) is a rare inflammatory disorder that classically presents with high spiking fevers, evanescent rash, and arthritis. The diagnosis is one of exclusion and can be further compl...

    Authors: Arash Mollaeian, Jingjing Chen, Nina N. Chan, Gregory A. Nizialek and Christopher J. Haas

    Citation: BMC Rheumatology 2021 5:12

    Content type: Case report

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    The Correction to this article has been published in BMC Rheumatology 2021 5:29

  31. Patients with idiopathic inflammatory myopathy and autoantibodies directed against melanoma differentiation-associated protein 5 (MDA5) characteristically have interstitial lung disease, severe cutaneous invol...

    Authors: Meghan E. Ryan, Daniel Cortez, Kelly R. Dietz, Peter Karachunski and Bryce A. Binstadt

    Citation: BMC Rheumatology 2021 5:8

    Content type: Case report

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  32. B cells are critical mediators of systemic lupus erythematosus (SLE) and lupus nephritis (LN), and antinuclear antibodies can be found in the serum of approximately 98% of patients with SLE. Spleen tyrosine ki...

    Authors: Christopher W. Pohlmeyer, Ching Shang, Pei Han, Zhi-Hua Cui, Randall M. Jones, Astrid S. Clarke, Bernard P. Murray, David A. Lopez, David W. Newstrom, M. David Inzunza, Franziska G. Matzkies, Kevin S. Currie and Julie A. Di Paolo

    Citation: BMC Rheumatology 2021 5:15

    Content type: Research article

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  33. Pyoderma gangrenosum (PG) is an uncommon, idiopathic, ulcerative neutrophilic dermatosis. In many cases, PG is associated with a wide variety of different disorders but SLE in association with PG is relatively...

    Authors: Sing Chiek Teoh, Chun Yang Sim, Seow Lin Chuah, Victoria Kok and Cheng Lay Teh

    Citation: BMC Rheumatology 2021 5:7

    Content type: Case report

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  34. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ruth E. Costello, Antonia Marsden, Mohammad Movahedi, Mark Lunt, Jenny H. Humphreys, Richard Emsley and William G. Dixon

    Citation: BMC Rheumatology 2021 5:11

    Content type: Correction

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    The original article was published in BMC Rheumatology 2020 4:4

  35. Low dose methotrexate toxicity rarely occurs, but may present with severe complications, such as pancytopenia, hepatotoxicity, mucositis, and pneumonitis. Known risk factors for methotrexate toxicity include d...

    Authors: Miguel A. Jara-Palacios, William Chun and Nomi L. Traub

    Citation: BMC Rheumatology 2021 5:5

    Content type: Case report

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  36. Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that causes chronic synovitis, resulting in progressive joint destruction and functional disability and affects approximately 400,000 people in t...

    Authors: Ernest Choy, Lara Groves, Daniel Sugrue, Michael Hurst, John Houghton, Srinivasan Venkatachalam, Yusuf I. Patel, James R. Maxwell, Kevin G. Pollock and Sadie Henning

    Citation: BMC Rheumatology 2021 5:3

    Content type: Research article

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  37. Fictional portrayals of illness and medical management in film and television can reflect and perpetuate cultural stereotypes about illness. The aim of this study was to analyse fictional depictions of gout in...

    Authors: Christina Derksen, Rachel Murdoch, Keith J. Petrie and Nicola Dalbeth

    Citation: BMC Rheumatology 2021 5:4

    Content type: Research article

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  38. The diagnosis of Behçet disease (BD) is challenging in many cases. The purpose of this study was to describe the clinical characteristics of patients at a referral BD clinic.

    Authors: Mina Kiafar, Seyedeh Tahereh Faezi, Amir Kasaeian, Azarakhsh Baghdadi, Sahar Kakaei, Seyed Ali Mousavi, Mohammad Nejadhosseinian, Farhad Shahram, Seyedeh Zahra Ghodsi, Hormoz Shams and Fereydoun Davatchi

    Citation: BMC Rheumatology 2021 5:2

    Content type: Research article

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  39. The activation of antigen specific T cells during an immune response is a tightly regulated process at the level of both costimulatory and coinhibitory receptors. One such coinhibitory receptor or checkpoint i...

    Authors: Mary Canavan, Achilleas Floudas, Douglas J. Veale and Ursula Fearon

    Citation: BMC Rheumatology 2021 5:1

    Content type: Review

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  40. Rheumatoid arthritis (RA) is characterized by systemic inflammation and bone and muscle loss. Recent research showed that obesity facilitates inflammation, but it is unknown if obesity also increases the risk ...

    Authors: Andreas Friedberger, Camille Figueiredo, Tobias Bäuerle, Georg Schett and Klaus Engelke

    Citation: BMC Rheumatology 2020 4:72

    Content type: Research article

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  41. Pain is the clinical hallmark of patients in patients with autoinflammatory diseases (AID) caused by variants of the NLRP3-, MEFV- or TNFRSF1A gene. However, no systematical analysis of the clinical and psycholog...

    Authors: Elisabeth Mulazzani, Nicole Zolyniak, Elisabeth Noe, Matthias Mulazzani, Shahnaz Christina Azad, Tania Kümpfel and Eduard Kraft

    Citation: BMC Rheumatology 2020 4:71

    Content type: Research article

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  42. Nationally representative data on burden of musculoskeletal conditions (MSK) in Bangladesh are not available. The objective of this study was to determine the prevalence of MSK conditions and related disabilit...

    Authors: Ahmad Zahid-Al-Quadir, M. Mostafa Zaman, Shamim Ahmed, Mahfuzur Rahman Bhuiyan, Md Mujibur Rahman, Ismail Patwary, Bidhu Bhushan Das, Shaikh Amir Hossain, Sujat Paul, Abu Shahin, Moshiur Rahman and Syed Atiqul Haq

    Citation: BMC Rheumatology 2020 4:69

    Content type: Research article

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  43. Antineutrophil cytoplasmic antibodies (ANCA) and Anti-glomerular basement membrane (GBM) antibodies often induce rapidly progressive glomerulonephritis (RPGN). Some reports have demonstrated RPGN with the sequ...

    Authors: Mikiya Kato, Risa Wakiya, Tomohiro Kameda, Kousuke Inoue, Tadashi Sofue, Yusuke Ushio, Koichi Sugihara, Shusaku Nakashima, Hiromi Shimada, Mai Mahmoud Fahmy Mansour, Norimitsu Kadowaki and Hiroaki Dobashi

    Citation: BMC Rheumatology 2020 4:68

    Content type: Case report

    Published on:

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