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  1. Content type: Research article

    The aim of this study was to identify predictors of prolonged disease control after discontinuation of tumor necrosis factor inhibitor (TNFi) treatment in patients with rheumatoid arthritis (RA).

    Authors: Marjan Ghiti Moghadam, Femke B. G. Lamers-Karnebeek, Harald E. Vonkeman, Peter M. ten Klooster, Janneke Tekstra, Barbara van Schaeybroeck, Ruth Klaasen, Marieke van Onna, Hein J. Bernelot Moens, Henk Visser, Annemarie M. Schilder, Marc R. Kok, Robert B. M. Landewé, Piet L. C. M. van Riel, Mart A. F. J. van de Laar and Tim L. Jansen

    Citation: BMC Rheumatology 2019 3:3

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  2. Content type: Research article

    Withdrawal of disease-modifying anti-rheumatic drugs (DMARDs) once disease remission is achieved is endorsed by current international rheumatoid arthritis (RA) management guidelines. However, very little data ...

    Authors: Kenneth F. Baker, John D. Isaacs and Ben Thompson

    Citation: BMC Rheumatology 2019 3:2

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  3. Content type: Research article

    A fatty corner lesion (FCL) is a well-demarcated fat infiltration in the corner of a vertebral body on T1 magnetic resonance imaging (MRI) sequence. It has been reported to be useful in the diagnosis of axial ...

    Authors: Ho Yin Chung, Rachel Sze Wan Yiu, Shirley Chiu Wai Chan, Kam Ho Lee and Chak Sing Lau

    Citation: BMC Rheumatology 2019 3:17

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  4. Content type: Research article

    Good communication is central to a high-quality consultation process. We assessed the quality of referral information from primary care physicians (PCPs) to rheumatologists and the quality and timeliness of co...

    Authors: Jenna Wong, Karen Tu, Sasha Bernatsky, Liisa Jaakkimainen, J. Carter Thorne, Vandana Ahluwalia, J. Michael Paterson and Jessica Widdifield

    Citation: BMC Rheumatology 2019 3:1

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  5. Content type: Research article

    Around 1 in 8 patients with axial spondyloarthritis (axSpA) also meet criteria for fibromyalgia and such patients have considerable unmet need. Identifying effective therapy is important but to what extent fib...

    Authors: Gary J. Macfarlane, Ejaz Pathan, Stefan Siebert, Jonathan Packham, Karl Gaffney, Ernest Choy, Raj Sengupta, Fabiola Atzeni, Kathryn R. Martin, Gareth T. Jones and Linda E. Dean

    Citation: BMC Rheumatology 2019 3:19

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  6. Content type: Research article

    With improved therapies and management, more women with inflammatory arthritides (IA) are considering pregnancy. Our objective was to survey rheumatologists across Canada about their IA management in pregnancy...

    Authors: Mary A. De Vera, Corisande Baldwin, Nicole W. Tsao, Alyssa Howren, Glen S. Hazlewood, Nevena Rebić and Stephanie Ensworth

    Citation: BMC Rheumatology 2019 3:18

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  7. Content type: Research article

    Adjusting medication of patients with rheumatoid arthritis (RA) until predefined disease activity targets are met, i.e. Treat-to-Target (T2T), is the currently recommended treatment approach. However, not much...

    Authors: Celine J. van de Laar, Martijn A. H. Oude Voshaar and Harald E. Vonkeman

    Citation: BMC Rheumatology 2019 3:16

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  8. Content type: Case report

    The details of two rheumatoid arthritis (RA) patients with systemic sclerosis (SSc) who were administered tocilizumab, an anti-interleukin-6 receptor antibody, are reported, along with a review of the literature.

    Authors: Hiroki Wakabayashi, Hitoshi Kino, Makoto Kondo, Keiichi Yamanaka, Masahiro Hasegawa and Akihiro Sudo

    Citation: BMC Rheumatology 2019 3:15

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  9. Content type: Case report

    The pathobiology of rheumatoid arthritis (RA) is similar to that of periodontitis in that proinflammatory cytokines play an important pathologic role. There is evidence to suggest that inhibitors of tumor necr...

    Authors: Tetsuo Kobayashi, Satoshi Ito, Akira Murasawa, Hajime Ishikawa and Hiromasa Yoshie

    Citation: BMC Rheumatology 2019 3:13

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  10. Content type: Research article

    The TITRATE trial seeks to test whether intensive management is valuable in achieving disease remission in moderately active rheumatoid arthritis. Intensive management is a complex intervention consisting of: ...

    Authors: Louise Prothero, Jackie Sturt, Savia de Souza and Heidi Lempp

    Citation: BMC Rheumatology 2019 3:12

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  11. Content type: Research article

    Uncontrolled gout can cause significant joint and organ damage and has been associated with impairments in quality of life and high economic cost. Gout has also been associated with other comorbid diseases, su...

    Authors: Dena H. Jaffe, Alyssa B. Klein, Arriel Benis, Natalia M. Flores, Hagit Gabay, Robert Morlock, Dana Y. Teltsch, Jonathan Chapnick, Yair Molad, Shmuel M. Giveon, Becca Feldman and Maya Leventer-Roberts

    Citation: BMC Rheumatology 2019 3:11

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  12. Content type: Research article

    Inhibitors of tumor necrosis factor alpha (TNF-α) are current mainstay of therapies for rheumatoid arthritis (RA). The decision when to withdraw TNF-α inhibitors after achieving remission and the incidence of ...

    Authors: Arduino A. Mangoni, Fahdah Al Okaily, Hani Almoallim, Seham Al Rashidi, Reem Hamdy A. Mohammed and Amal Barbary

    Citation: BMC Rheumatology 2019 3:10

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  13. Content type: Research article

    Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) are characterized by autoimmune small vessel inflammation. Eosinophils are multifunctional cells with both pro-inflammatory and immunoregula...

    Authors: Thomas Hellmark, Sophie Ohlsson, Åsa Pettersson, Markus Hansson and Åsa C. M. Johansson

    Citation: BMC Rheumatology 2019 3:9

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  14. Content type: Research article

    Signs and symptoms establish the diagnosis of adult onset Still’s disease (AOSD) as well as of systemic onset juvenile idiopathic arthritis (sJIA). The published data regarding the importance of IL-18 as a mar...

    Authors: Holger Kudela, Susanne Drynda, Anke Lux, Gerd Horneff and Joern Kekow

    Citation: BMC Rheumatology 2019 3:4

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  15. Content type: Research article

    The emphasis on treating rheumatoid arthritis (RA) intensively reduces disease activity but its impact in routine care is uncertain. We evaluated temporal changes in disease activities and outcomes in a 10-yea...

    Authors: Nicola J. Gullick, Fowzia Ibrahim, Ian C. Scott, Alexandra Vincent, Andrew P. Cope, Toby Garrood, Gabriel S. Panayi, David L. Scott and Bruce W. Kirkham

    Citation: BMC Rheumatology 2019 3:6

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  16. Content type: Case report

    Hemophagocytic lymphohistiocytosis (HLH) is a severe clinical entity associated with high mortality in the adult population. HLH has been associated with infections, malignancy and autoimmune conditions such a...

    Authors: Christina S. Thornton, Parham Minoo, Michelle Schneider and Aurore Fifi-Mah

    Citation: BMC Rheumatology 2019 3:7

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  17. Content type: Research article

    Rheumatoid arthritis is an autoimmune disease that causes joint inflammation. It affects around 400,000 people in the UK and 1 million adults in the USA. Given the appropriate treatment, many can have relative...

    Authors: Fran Toye, Kate Seers and Karen Louise Barker

    Citation: BMC Rheumatology 2019 3:5

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  18. Content type: Research article

    Biomarkers of rheumatoid arthritis (RA) disease activity typically measure inflammation or autoimmunity (e.g. CRP, RF). C1M and C3M, metabolites of type I and III collagen, are markers reflecting tissue metabo...

    Authors: Anne C. Bay-Jensen, Adam Platt, Martin A. Jenkins, Michael E. Weinblatt, Inger Byrjalsen, Kishwar Musa, Mark C. Genovese and Morten A. Karsdal

    Citation: BMC Rheumatology 2019 3:3

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  19. Content type: Study protocol

    Fibromyalgia is characterized by chronic generalized pain, fatigue, sleep disorders and other symptoms. Physical exercise is recommended as the first choice of non-pharmacological therapy. Thus, the aim of thi...

    Authors: Katherinne Ferro Moura Franco, Yuri Rafael dos Santos Franco, Evany Maira Espírito Santo Salvador, Bruna Cristina Brajon do Nascimento, Gisela Cristiane Miyamoto and Cristina Maria Nunes Cabral

    Citation: BMC Rheumatology 2019 3:2

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  20. Content type: Research article

    Tumour necrosis factor inhibitor (TNFi) therapy has been available for rheumatoid arthritis (RA) patients for several decades but data on the long-term risk of malignancy associated with its use is limited. Ou...

    Authors: Margaret P. Staples, Lyn March, Catherine Hill, Marissa Lassere and Rachelle Buchbinder

    Citation: BMC Rheumatology 2019 3:1

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  21. Content type: Research article

    Fibromyalgia (FM) is a complex, centralized pain condition that is often difficult to diagnose and treat. FM is considered to have a genetic background due to its familial aggregation and due to findings from ...

    Authors: Chee Lee, Ginevra Liptan, Svetlana Kantorovich, Maneesh Sharma and Ashley Brenton

    Citation: BMC Rheumatology 2018 2:38

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  22. Content type: Case report

    Autoimmune disorders are known to produce false positives in serological tests for infections. Aetiological association between infections and autoimmunity, increased susceptibility to infectious and autoimmun...

    Authors: Harsha Anuruddhika Dissanayake, Gayani Premawansa, Enoka Corea and Inoshi Atukorale

    Citation: BMC Rheumatology 2018 2:37

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  23. Content type: Research article

    To investigate the incidence and the mortality-rates of systemic sclerosis (SSc), its primary causes of death, and the temporal trends in events in Denmark during the last decades.

    Authors: Sheraz A. Butt, Jørgen L. Jeppesen, Christine Fuchs, Mette Mogensen, Merete Engelhart, Christian Torp-Pedersen, Gunnar H. Gislason, Søren Jacobsen and Charlotte Andersson

    Citation: BMC Rheumatology 2018 2:36

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  24. Content type: Research article

    To understand the roles of serum exosomes in rheumatoid arthritis (RA), we comprehensively investigated the protein profiles of serum exosomes in patients with RA.

    Authors: Hirotaka Tsuno, Mitsumi Arito, Naoya Suematsu, Toshiyuki Sato, Atsushi Hashimoto, Toshihiro Matsui, Kazuki Omoteyama, Masaaki Sato, Kazuki Okamoto, Shigeto Tohma, Manae S. Kurokawa and Tomohiro Kato

    Citation: BMC Rheumatology 2018 2:35

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  25. Content type: Research article

    The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized as both inflammatory and fibrotic. The current ...

    Authors: Julie Stougaard, Søren Lomholt, Pernille Ommen, Jens Kelsen and Tue W. Kragstrup

    Citation: BMC Rheumatology 2018 2:33

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  26. Content type: Research article

    There is increasing interest in the identification of people at risk of rheumatoid arthritis (RA) to monitor the emergence of early symptoms (and thus allow early therapy), offer lifestyle advice to reduce the...

    Authors: Gwenda Simons, Rebecca J Stack, Michaela Stoffer-Marx, Matthias Englbrecht, Erika Mosor, Christopher D Buckley, Kanta Kumar, Mats Hansson, Axel Hueber, Tanja Stamm, Marie Falahee and Karim Raza

    Citation: BMC Rheumatology 2018 2:31

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  27. Content type: Case report

    We report the case of a patient with rheumatoid arthritis (RA) treated with tofacitinib who developed severe Pneumocystis jirovecii pneumonia (PJP) with an atypical clinical presentation.

    Authors: Ian F. J. Pirker, Jacqueline Krane-Nuber, Werner C. Albrich, Rüdiger Müller and Thomas Neumann

    Citation: BMC Rheumatology 2018 2:34

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  28. Content type: Research article

    Osteoarthritis (OA) is diagnosed and managed primarily by general practitioners (GPs). OA guidelines recommend using clinical criteria, without x-ray, for diagnosis, and advising strengthening exercise, aerobi...

    Authors: Thorlene Egerton, Rachel K Nelligan, Jenny Setchell, Lou Atkins and Kim L Bennell

    Citation: BMC Rheumatology 2018 2:30

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  29. Content type: Research article

    Resveratrol is a natural polyphenol found in berries, roots and wine that is well known to have anti-inflammatory and anti-oxidative properties. The anti-inflammatory effect has been reported for both immune c...

    Authors: S. Lomholt, A. Mellemkjaer, M. B. Iversen, S. B. Pedersen and T. W. Kragstrup

    Citation: BMC Rheumatology 2018 2:27

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  30. Content type: Research article

    Fibromyalgia is a debilitating condition, characterized by extensive muscular pain and fatigue. Vitamin D is essential for overall health, with ubiquitous involvement in various inflammatory and pain pathways....

    Authors: Shawn D. Ellis, Sam T. Kelly, Jonathan H. Shurlock and Alastair L. N. Hepburn

    Citation: BMC Rheumatology 2018 2:28

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  31. Content type: Research article

    To evaluate demographics, family history, and previous medication use at enrollment in a subset of psoriasis patients with self-reported psoriatic arthritis (PsA) enrolled in Psoriasis Longitudinal Assessment ...

    Authors: Arthur Kavanaugh, Kim Papp, Alice B. Gottlieb, Elke M. G. J. de Jong, Soumya D. Chakravarty, Shelly Kafka, Wayne Langholff, Kamyar Farahi, Bhaskar Srivastava and Jose U. Scher

    Citation: BMC Rheumatology 2018 2:29

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  32. Content type: Research article

    Vitamin D has been implicated as being involved in the aetio-pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA). Previous studies present contradictory results. Vitamin D binding p...

    Authors: Mikael Brink, Linda Johansson, Evelina Nygren, Lisbeth Ärlestig, Johan Hultdin and Solbritt Rantapää-Dahlqvist

    Citation: BMC Rheumatology 2018 2:26

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  33. Content type: Research article

    Chronic inflammatory arthritis is associated with increased cardiovascular (CV) morbidity and mortality. Pharmacological management and healthy lifestyle modification is recommended to manage these risks, but ...

    Authors: Premarani Sinnathurai, Alexandra Capon, Rachelle Buchbinder, Vibhasha Chand, Lyndall Henderson, Marissa Lassere and Lyn March

    Citation: BMC Rheumatology 2018 2:25

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  34. Content type: Research article

    Anti-cytokine therapies such as adalimumab, tocilizumab, and the small molecule JAK inhibitor tofacitinib have proven that cytokines and their subsequent downstream signaling processes are important in the pat...

    Authors: Julie M. Parmentier, Jeff Voss, Candace Graff, Annette Schwartz, Maria Argiriadi, Michael Friedman, Heidi S. Camp, Robert J. Padley, Jonathan S. George, Deborah Hyland, Matthew Rosebraugh, Neil Wishart, Lisa Olson and Andrew J. Long

    Citation: BMC Rheumatology 2018 2:23

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  35. Content type: Research article

    Although psoriatic arthritis is complex and involves multiple domains, recent advances in treatments have made remission or near-remission of most symptoms a potentially achievable goal for many patients. We s...

    Authors: Laura C. Coates, Ana-Maria Orbai, Akimichi Morita, Olivier Benichou, Lisa Kerr, David H. Adams, Catherine L. Shuler, Julie Birt and Philip S. Helliwell

    Citation: BMC Rheumatology 2018 2:24

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  36. Content type: Research article

    Autoimmune rheumatic diseases (ARDs) such as inflammatory arthritis and Lupus, and many of the treatments for these diseases, can have a detrimental impact on fertility and pregnancy outcomes. Disease activity...

    Authors: Rhiannon Phillips, Bethan Pell, Aimee Grant, Daniel Bowen, Julia Sanders, Ann Taylor, Adrian Edwards, Ernest Choy and Denitza Williams

    Citation: BMC Rheumatology 2018 2:21

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  37. Content type: Case report

    Takayasu arteritis is a rare large vessel vasculitis which predominantly affects young Asian females. Aortic regurgitation and heart failure are well described manifestations which are usually preceded by cons...

    Authors: Nipun Lakshitha de Silva, Milinda Withana, Praveen Weeratunga, Prakash Priyadharshana and Inoshi Atukorala

    Citation: BMC Rheumatology 2018 2:20

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  38. Content type: Research article

    There is growing evidence that it may be possible to identify people at high risk of developing rheumatoid arthritis (RA). Assuming that effective interventions were available, this could mean that treatments ...

    Authors: Sarah Munro, Luke Spooner, Katherine Milbers, Marie Hudson, Cheryl Koehn and Mark Harrison

    Citation: BMC Rheumatology 2018 2:18

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  39. Content type: Case report

    Behcet’s disease and Sjogren’s syndrome is an autoimmune disorder from which many systems of the body can suffer. Here we reported a patient with a history of Behcet’s disease and Sjogren’s syndrome in which R...

    Authors: Fulong Xiao, Jun Zhang, Waner Wang, Xuehua Wang, Wei Zhang, Liyue Xu and Fang Han

    Citation: BMC Rheumatology 2018 2:19

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  40. Content type: Research article

    Clinical response and remission are defined in multiple ways and measured with different instruments, resulting in substantial variation of the proportion of patients classified as being in remission. Therefor...

    Authors: Samina A. Turk, Linda A. Rasch, Dirkjan van Schaardenburg, Willem F. Lems, Marjolein Sanberg, Lilian H. D. van Tuyl and Marieke M. ter Wee

    Citation: BMC Rheumatology 2018 2:16

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  41. Content type: Research article

    Patients with metabolic syndrome (MetS) are at increased risk of asymptomatic hyperuricemia (i.e., elevated serum uric acid (SUA) level without gout) and cardiovascular disease. We conducted a cross-sectional ...

    Authors: Seoyoung C. Kim, Marcelo F. Di Carli, Rajesh K. Garg, Kathleen Vanni, Penny Wang, Alyssa Wohlfahrt, Zhi Yu, Fengxin Lu, Anarosa Campos, Courtney F. Bibbo, Stacy Smith and Daniel H. Solomon

    Citation: BMC Rheumatology 2018 2:17

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  42. Content type: Research article

    This study aimed to explore the beliefs of people with knee osteoarthritis (OA) about the disease, and how these beliefs had formed and what impact these beliefs had on activity participation, health behaviour...

    Authors: Ben Darlow, Melanie Brown, Bronwyn Thompson, Ben Hudson, Rebecca Grainger, Eileen McKinlay and J. Haxby Abbott

    Citation: BMC Rheumatology 2018 2:15

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  43. Content type: Research article

    This study analyzed visits for and factors associated with gout and gout medication treatment trends for the years 2007–2011 in the United States given the introduction of febuxostat, the first new treatment o...

    Authors: Kristen E. Castro, Kaitlyn D. Corey, Diana L. Raymond, Michael R. Jiroutek and Melissa A. Holland

    Citation: BMC Rheumatology 2018 2:14

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  44. Content type: Research article

    Systemic Sclerosis is a multifactorial autoimmune rheumatic disease characterized by inflammation, fibrosis, immune dysregulation and vascular dysfunction.

    Authors: Annemarie Schorpion, Max Shenin, Robin Neubauer and Chris T. Derk

    Citation: BMC Rheumatology 2018 2:13

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  45. Content type: Review

    Cardiovascular disease (CVD) is markedly increased in patients with rheumatoid arthritis partly due to accelerated atherosclerosis from chronic inflammation. Traditional cardiovascular risk factors such as hyp...

    Authors: Aprajita Jagpal and Iris Navarro-Millán

    Citation: BMC Rheumatology 2018 2:10

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  46. Content type: Research article

    Pneumococcal vaccination is recommended to patients with rheumatoid arthritis (RA) and primary Sjögren’s syndrome (pSS). However, little is known whether the diseases influence pneumococcal vaccine response. T...

    Authors: Per Nived, Tore Saxne, Pierre Geborek, Thomas Mandl, Lillemor Skattum and Meliha C. Kapetanovic

    Citation: BMC Rheumatology 2018 2:12

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  47. Content type: Research article

    Chronic pain, regional or widespread, is a frequent and multidimensional symptom in arthritis. There is still limited information on chronic pain in spondyloarthritis, which is important to recognize for adequ...

    Authors: Elisabeth Mogard, Ann Bremander, Elisabet Lindqvist and Stefan Bergman

    Citation: BMC Rheumatology 2018 2:11

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