Hypogammaglobulinemia is a complication of B-cell targeting therapies (BCTT), used in vasculitis, rheumatoid arthritis and systemic lupus erythematosus (SLE). Since autoimmune diseases are associated with unde...
Authors: M. J. Cuadrado, I. Calatayud, M. Urquizu-Padilla, S. Wijetilleka, S. Kiani-Alikhan and M. Y. Karim
An error occurred during the publication of a number of articles in BMC Rheumatology. Several articles were published in volume 3 with a duplicate citation number.
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects joints with some extraarticular involvement. If inappropriately treated, it usually results in persistent joint pain, i...
Authors: Wanruchada Katchamart, Pongthorn Narongroeknawin, Wanwisa Chanapai and Phakhamon Thaweeratthakul
The objective of this study was to explore the associations between ultrasonographic and radiographic joint scores and levels of arterial CVD risk markers in patients with osteoarthritis (OA). Secondly, to com...
Authors: S. A. Provan, S. Rollefstad, E. Ikdahl, A. Mathiessen, I. J. Berg, I. Eeg, I. B. Wilkinson, C. M. McEniery, T. K. Kvien, H. B. Hammer, N. Østerås, I. K. Haugen and A. G. Semb
Concurrent presentation of retinal vasculitis with mixed sclerotic and lytic bone lesions is rare.
Authors: Victoria K. Shanmugam, Marc Phillpotts, Timothy Brady, Monica Dalal, Shawn Haji-Momenian, Esma Akin, Kavita Nataranjan, Sean McNish and Donald S. Karcher
Administrative database research is widely applied in the field of epidemiology. However, the results of the studies depend on the type of database used and the algorithms applied for case ascertainment. The o...
Authors: Kati Otsa, Sandra Talli, Pille Harding, Eevi Parsik, Marge Esko, Anti Teepere and Marika Tammaru
Rheumatoid arthritis (RA) is a chronic inflammatory and destructive arthritis. Understanding the incidence and prevalence of RA within the province facilitates appropriate health care resource planning.
Authors: Bindu Nair, Regina Taylor-Gjevre, Liying Wu, Shan Jin and Jacqueline M. Quail
Methods of gout flare reporting in research settings are inconsistent and poorly defined. The aim of this study was to describe patterns of gout flare and assess the concurrent validity of different methods of...
Authors: Novell Teoh, Gregory D. Gamble, Anne Horne, William J. Taylor, Kate Palmano and Nicola Dalbeth
Heterogeneity in assessments of rheumatoid arthritis (RA) disease remission, based on physician judgment and patient self-reports versus standardized measures, have previously been reported. This study explore...
Authors: Wenhui Wei, Emma Sullivan, Stuart Blackburn, Chieh-I Chen, James Piercy and Jeffrey R. Curtis
Previous studies of prognosis for women with Fibromyalgia (FM) or chronic widespread pain (CWP) show contradictory results. However, some women appear to improve in pain and other core symptoms over time. Ther...
Authors: Anna Bergenheim, Sofia Juhlin, Lena Nordeman, Monica Joelsson and Kaisa Mannerkorpi
The role of self-care behaviors in promoting physical function, pain management, health status and quality of life among patients with Rheumatoid Arthritis (RA) is well documented. However, there is no valid a...
Authors: Haidar Nadrian, Yasna Hosseini Niaz, Zahra Basiri and Ahmad Tahamoli Roudsari
Withdrawal of disease-modifying anti-rheumatic drugs (DMARDs) once disease remission is achieved is endorsed by current international rheumatoid arthritis (RA) management guidelines. However, very little data ...
Authors: Kenneth F. Baker, John D. Isaacs and Ben Thompson
The aim of this study was to identify predictors of prolonged disease control after discontinuation of tumor necrosis factor inhibitor (TNFi) treatment in patients with rheumatoid arthritis (RA).
Authors: Marjan Ghiti Moghadam, Femke B. G. Lamers-Karnebeek, Harald E. Vonkeman, Peter M. ten Klooster, Janneke Tekstra, Barbara van Schaeybroeck, Ruth Klaasen, Marieke van Onna, Hein J. Bernelot Moens, Henk Visser, Annemarie M. Schilder, Marc R. Kok, Robert B. M. Landewé, Piet L. C. M. van Riel, Mart A. F. J. van de Laar and Tim L. Jansen
A fatty corner lesion (FCL) is a well-demarcated fat infiltration in the corner of a vertebral body on T1 magnetic resonance imaging (MRI) sequence. It has been reported to be useful in the diagnosis of axial ...
Authors: Ho Yin Chung, Rachel Sze Wan Yiu, Shirley Chiu Wai Chan, Kam Ho Lee and Chak Sing Lau
Good communication is central to a high-quality consultation process. We assessed the quality of referral information from primary care physicians (PCPs) to rheumatologists and the quality and timeliness of co...
Authors: Jenna Wong, Karen Tu, Sasha Bernatsky, Liisa Jaakkimainen, J. Carter Thorne, Vandana Ahluwalia, J. Michael Paterson and Jessica Widdifield
Around 1 in 8 patients with axial spondyloarthritis (axSpA) also meet criteria for fibromyalgia and such patients have considerable unmet need. Identifying effective therapy is important but to what extent fib...
Authors: Gary J. Macfarlane, Ejaz Pathan, Stefan Siebert, Jonathan Packham, Karl Gaffney, Ernest Choy, Raj Sengupta, Fabiola Atzeni, Kathryn R. Martin, Gareth T. Jones and Linda E. Dean
With improved therapies and management, more women with inflammatory arthritides (IA) are considering pregnancy. Our objective was to survey rheumatologists across Canada about their IA management in pregnancy...
Authors: Mary A. De Vera, Corisande Baldwin, Nicole W. Tsao, Alyssa Howren, Glen S. Hazlewood, Nevena Rebić and Stephanie Ensworth
Adjusting medication of patients with rheumatoid arthritis (RA) until predefined disease activity targets are met, i.e. Treat-to-Target (T2T), is the currently recommended treatment approach. However, not much...
Authors: Celine J. van de Laar, Martijn A. H. Oude Voshaar and Harald E. Vonkeman
The details of two rheumatoid arthritis (RA) patients with systemic sclerosis (SSc) who were administered tocilizumab, an anti-interleukin-6 receptor antibody, are reported, along with a review of the literature.
The pathobiology of rheumatoid arthritis (RA) is similar to that of periodontitis in that proinflammatory cytokines play an important pathologic role. There is evidence to suggest that inhibitors of tumor necr...
The TITRATE trial seeks to test whether intensive management is valuable in achieving disease remission in moderately active rheumatoid arthritis. Intensive management is a complex intervention consisting of: ...
Authors: Louise Prothero, Jackie Sturt, Savia de Souza and Heidi Lempp
Uncontrolled gout can cause significant joint and organ damage and has been associated with impairments in quality of life and high economic cost. Gout has also been associated with other comorbid diseases, su...
Authors: Dena H. Jaffe, Alyssa B. Klein, Arriel Benis, Natalia M. Flores, Hagit Gabay, Robert Morlock, Dana Y. Teltsch, Jonathan Chapnick, Yair Molad, Shmuel M. Giveon, Becca Feldman and Maya Leventer-Roberts
Inhibitors of tumor necrosis factor alpha (TNF-α) are current mainstay of therapies for rheumatoid arthritis (RA). The decision when to withdraw TNF-α inhibitors after achieving remission and the incidence of ...
Authors: Arduino A. Mangoni, Fahdah Al Okaily, Hani Almoallim, Seham Al Rashidi, Reem Hamdy A. Mohammed and Amal Barbary
Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) are characterized by autoimmune small vessel inflammation. Eosinophils are multifunctional cells with both pro-inflammatory and immunoregula...
Authors: Thomas Hellmark, Sophie Ohlsson, Åsa Pettersson, Markus Hansson and Åsa C. M. Johansson
Signs and symptoms establish the diagnosis of adult onset Still’s disease (AOSD) as well as of systemic onset juvenile idiopathic arthritis (sJIA). The published data regarding the importance of IL-18 as a mar...
Authors: Holger Kudela, Susanne Drynda, Anke Lux, Gerd Horneff and Joern Kekow
The emphasis on treating rheumatoid arthritis (RA) intensively reduces disease activity but its impact in routine care is uncertain. We evaluated temporal changes in disease activities and outcomes in a 10-yea...
Authors: Nicola J. Gullick, Fowzia Ibrahim, Ian C. Scott, Alexandra Vincent, Andrew P. Cope, Toby Garrood, Gabriel S. Panayi, David L. Scott and Bruce W. Kirkham
Hemophagocytic lymphohistiocytosis (HLH) is a severe clinical entity associated with high mortality in the adult population. HLH has been associated with infections, malignancy and autoimmune conditions such a...
Authors: Christina S. Thornton, Parham Minoo, Michelle Schneider and Aurore Fifi-Mah
Rheumatoid arthritis is an autoimmune disease that causes joint inflammation. It affects around 400,000 people in the UK and 1 million adults in the USA. Given the appropriate treatment, many can have relative...
Authors: Fran Toye, Kate Seers and Karen Louise Barker
Biomarkers of rheumatoid arthritis (RA) disease activity typically measure inflammation or autoimmunity (e.g. CRP, RF). C1M and C3M, metabolites of type I and III collagen, are markers reflecting tissue metabo...
Authors: Anne C. Bay-Jensen, Adam Platt, Martin A. Jenkins, Michael E. Weinblatt, Inger Byrjalsen, Kishwar Musa, Mark C. Genovese and Morten A. Karsdal
Fibromyalgia is characterized by chronic generalized pain, fatigue, sleep disorders and other symptoms. Physical exercise is recommended as the first choice of non-pharmacological therapy. Thus, the aim of thi...
Authors: Katherinne Ferro Moura Franco, Yuri Rafael dos Santos Franco, Evany Maira Espírito Santo Salvador, Bruna Cristina Brajon do Nascimento, Gisela Cristiane Miyamoto and Cristina Maria Nunes Cabral
Tumour necrosis factor inhibitor (TNFi) therapy has been available for rheumatoid arthritis (RA) patients for several decades but data on the long-term risk of malignancy associated with its use is limited. Ou...
Authors: Margaret P. Staples, Lyn March, Catherine Hill, Marissa Lassere and Rachelle Buchbinder
Fibromyalgia (FM) is a complex, centralized pain condition that is often difficult to diagnose and treat. FM is considered to have a genetic background due to its familial aggregation and due to findings from ...
Autoimmune disorders are known to produce false positives in serological tests for infections. Aetiological association between infections and autoimmunity, increased susceptibility to infectious and autoimmun...
To investigate the incidence and the mortality-rates of systemic sclerosis (SSc), its primary causes of death, and the temporal trends in events in Denmark during the last decades.
Authors: Sheraz A. Butt, Jørgen L. Jeppesen, Christine Fuchs, Mette Mogensen, Merete Engelhart, Christian Torp-Pedersen, Gunnar H. Gislason, Søren Jacobsen and Charlotte Andersson
To understand the roles of serum exosomes in rheumatoid arthritis (RA), we comprehensively investigated the protein profiles of serum exosomes in patients with RA.
The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized as both inflammatory and fibrotic. The current ...
Authors: Julie Stougaard, Søren Lomholt, Pernille Ommen, Jens Kelsen and Tue W. Kragstrup
There is increasing interest in the identification of people at risk of rheumatoid arthritis (RA) to monitor the emergence of early symptoms (and thus allow early therapy), offer lifestyle advice to reduce the...
Authors: Gwenda Simons, Rebecca J Stack, Michaela Stoffer-Marx, Matthias Englbrecht, Erika Mosor, Christopher D Buckley, Kanta Kumar, Mats Hansson, Axel Hueber, Tanja Stamm, Marie Falahee and Karim Raza
We report the case of a patient with rheumatoid arthritis (RA) treated with tofacitinib who developed severe Pneumocystis jirovecii pneumonia (PJP) with an atypical clinical presentation.
Authors: Ian F. J. Pirker, Jacqueline Krane-Nuber, Werner C. Albrich, Rüdiger Müller and Thomas Neumann
Although treat-to-target has revolutionised the outcomes of patients with rheumatoid arthritis (RA) there is emerging evidence that attaining the target of remission is insufficient to normalise patients’ qual...
Authors: I. C. Scott, A. Machin, C. D. Mallen and S. L. Hider
Osteoarthritis (OA) is diagnosed and managed primarily by general practitioners (GPs). OA guidelines recommend using clinical criteria, without x-ray, for diagnosis, and advising strengthening exercise, aerobi...
Authors: Thorlene Egerton, Rachel K Nelligan, Jenny Setchell, Lou Atkins and Kim L Bennell
Resveratrol is a natural polyphenol found in berries, roots and wine that is well known to have anti-inflammatory and anti-oxidative properties. The anti-inflammatory effect has been reported for both immune c...
Authors: S. Lomholt, A. Mellemkjaer, M. B. Iversen, S. B. Pedersen and T. W. Kragstrup
Fibromyalgia is a debilitating condition, characterized by extensive muscular pain and fatigue. Vitamin D is essential for overall health, with ubiquitous involvement in various inflammatory and pain pathways....
Authors: Shawn D. Ellis, Sam T. Kelly, Jonathan H. Shurlock and Alastair L. N. Hepburn
To evaluate demographics, family history, and previous medication use at enrollment in a subset of psoriasis patients with self-reported psoriatic arthritis (PsA) enrolled in Psoriasis Longitudinal Assessment ...
Authors: Arthur Kavanaugh, Kim Papp, Alice B. Gottlieb, Elke M. G. J. de Jong, Soumya D. Chakravarty, Shelly Kafka, Wayne Langholff, Kamyar Farahi, Bhaskar Srivastava and Jose U. Scher
Vitamin D has been implicated as being involved in the aetio-pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA). Previous studies present contradictory results. Vitamin D binding p...
Authors: Mikael Brink, Linda Johansson, Evelina Nygren, Lisbeth Ärlestig, Johan Hultdin and Solbritt Rantapää-Dahlqvist
Chronic inflammatory arthritis is associated with increased cardiovascular (CV) morbidity and mortality. Pharmacological management and healthy lifestyle modification is recommended to manage these risks, but ...
Authors: Premarani Sinnathurai, Alexandra Capon, Rachelle Buchbinder, Vibhasha Chand, Lyndall Henderson, Marissa Lassere and Lyn March
Anti-cytokine therapies such as adalimumab, tocilizumab, and the small molecule JAK inhibitor tofacitinib have proven that cytokines and their subsequent downstream signaling processes are important in the pat...
Authors: Julie M. Parmentier, Jeff Voss, Candace Graff, Annette Schwartz, Maria Argiriadi, Michael Friedman, Heidi S. Camp, Robert J. Padley, Jonathan S. George, Deborah Hyland, Matthew Rosebraugh, Neil Wishart, Lisa Olson and Andrew J. Long
Although psoriatic arthritis is complex and involves multiple domains, recent advances in treatments have made remission or near-remission of most symptoms a potentially achievable goal for many patients. We s...
Authors: Laura C. Coates, Ana-Maria Orbai, Akimichi Morita, Olivier Benichou, Lisa Kerr, David H. Adams, Catherine L. Shuler, Julie Birt and Philip S. Helliwell
