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Table 3 Proteins identified by mass spectrometry

From: A proteomic analysis of serum-derived exosomes in rheumatoid arthritis

Spot ID Observed Fold difference Protein Theoretical Masscot Score Coverage (%) Confirmed Sequences (Masscot ion score) Search log
MW pI wRA OA HL MW pI
aRA iRA
208 90 5.3 1.4* 1.0 1.0 Pro-neuregulin-3, membrane-bound isoform 78 7.8 61 12 388QAKQIQEQLK397(19) 38,220
NRG3_HUMAN
236 87 5.1 1.1 1.3* 1.0 Cathepsin F 53 8.5 26 3 103TLLCSFQVLDELGRHVLLR121(26) 38,210
CATF_HUMAN peptide summary
325 65 5.1 0.9 0.7* 1.0 Ig alpha-2 chain C region 37 5.7 132 10 251WLQGSQELPR260(53) 38,207
IGHA2_HUMAN 270QEPSQGTTTFAVTSILR286(70)
370 53 5.1 1.3* 0.9 0.9 1.0 Alpha-1-antitrypsin 47 5.4 170 33 50ITPNLAEFAFSLYR63(79) 38,190
A1AT_HUMAN 216GKWERPFEVK225(10)
494 40 7.0 0.7* 0.9 0.9 1.0 Keratin, type II cytoskeletal 1 66 8.2 62 9 212WELLQQVDTSTR223(14) 38,206
K2C1_HUMAN 224THNLEPYFESFINNLR239(41)
564 24 5.2 6.3* 1.2 1.1 1.0 Toll-like receptor 3 104 6.7 68 19 532LEILDLQHNNLAR544(7) 38,215
TLR3_HUMAN
  1. MW molecular weight, wRA whole RA, aRA active RA, iRA inactive RA, OA osteoarthritis, HL healthy donor
  2. Fold differences are shown with the intensity of the protein spots in HLs defined as 1.0. Asterisks indicate that the spot intensity is significantly different (p < 0.05) from that in HLs