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Table 2 Clinical and laboratory characteristics of children’s cohort

From: Comparative study of Interleukin-18 (IL-18) serum levels in adult onset Still’s disease (AOSD) and systemic onset juvenile idiopathic arthritis (sJIA) and its use as a biomarker for diagnosis and evaluation of disease activity

  sJIA Non-sJIA comparison group in children
Number 20 23
Mean age in years (SD; Range) 9.6 (±5.5; 2–17) 7.8 (±5.1; 11 Mon.-17)
Sex (male:female) 1.2:1 1:1.1
Swollen joints per patient* n (Range) 0.5 (0–10) 0 (0–8)
Patients with swollen joints n (%) 10 (50) 4 (12.5)
Tender joints per patient* n (Range) 1 (0–10) 0 (0–8)
Patients with tender joints n (%) 12 (60) 5 (15.6)
Arthralgia n (%) 14 (70) 9 (39.1)
Erosive Arthritis n 0 0
Fever n (%) 16 (80) 16 (69.6)
Rash n (%) 12 (60) 3 (13)
Pharyngitis/sore throat n (%) 4 (20) 1 (4.3)
Splenomegaly n (%) 3 (15) 2 (8.7)
Lymphadenopathy n (%) 0 (0) 4 (17.4)
Serositis (Pleuritis/Pericarditis/Peritonitis) n (%) 2 (10) 3 (13)
Prednisolone Therapy at IL-18 determination n (%) 5 (25) 4 (17.4)
DMARD Therapy 2 (10) 2 (8.7)
WBC > 10,000/ml n (%) 16 (80) 11 (47.8)
WBC Gpt/ml (SD; Range) 15.1 (± 8.3; 5.6–37.7) 12.8 (± 8.4; 3.6–32.8)
Neutrophils > 80% n (%) 8 (40) 5 (21.7)
ANA > 1:160 n (%) 0 (0). 6 x not examined 2 (8.7) 8 x not examined
Elevated ALT or AST n (%) 1 (5) 2 (8.7)
ALAT μmol/ls (SD) 0.3 (±0.20; 0.07–0.72) 0.35 (±0.21; 0.1–0.87)
RF positive n (%) 2 (7 x of 20 not examined) 1 (8 x of 23 not examined)
CRP mg/l (SD; Range) 0 (8 x of 20 not examined) 0 (13 x of 23 not examined)
ESR mm/1 h (SD; Range) 115.1 (±85.4; < 5–398.8) 70.6 (±74.6; < 5–253.4)
WBC > 10,000/ml n (%) 70.0 (±48.9; 2–147; 12 x not examined) 51.1 (±42.4; 5–125; 16 x not examined)
RBC Tpt/l (SD; Range) 4.46 (±0.53; 3.4–5.53) 4.33 (±0.51; 3.15–5.47)
Hemoglobin mmol/l (SD; Range) 8.3 (±2.1; 6–12) 8.4 (±2.46; 5.2–13.8)
Hematocrit % (SD; Range) 0.35 (±0.04;0.29–0.46) 0.34 (±0.04;0.26–0.42)
Platelets Gpt/l (SD; Range) 409.2 (±178.8; 166–687) 360.4 (±124.5; 183–660)
IL-18 pg/ml* (Range) 14,732.5 (215–372,850) 2580 (346.2–141,650)
  1. *Median; SD Standard Deviation, n number, DMARD disease modifying antirheumatic drug, WBC white blood cell count, ANA antinuclear antibodies, ALT alanine transaminase, AST aspartate transaminase, RF rheumatoid factor, CRP C-reactive protein, ESR erythrocyte sedimentation rate, RBC red blood cell count