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Table 4 Differences in clinical and patient reported characteristics (not used in clustering) across clusters (fibromyalgia positive participants)

From: AxSpA patients who also meet criteria for fibromyalgia: identifying distinct patient clusters using data from a UK national register (BSRBR-AS)

 

Cluster 1

Cluster 2

Cluster 3

 

N (%)

N (%)

N (%)

p value

Gender

 male

4 (23.5)

94 (59.9)a

63 (52.5)

p = 0.014

 female

13 (76.5)

63 (40.1)

57 (47.5)

Smoking Status

 never

5 (29.4)

53 (34.2)

51 (43.6)

p = 0.027

 ex

6 (35.3)

52 (33.5)

48 (41.0)

 current

6 (35.3)

50 (32.3)

18 (15.4)

Alcohol Use

 never

1 (5.9)

21 (13.5)

13 (11.1)

p = 0.032

 ex

7 (41.2)

50 (32.3)

21 (18.0)

 current

9 (52.9)

84 (54.2)

83 (70.9)

Employed

 no

8 (47.1)

85 (54.1)

47 (39.5)

p = 0.054

 yes

9 (52.9)

72 (45.9)

72 (60.5)

Job type

 mainly sedentary

1 (12.5)

30 (43.5)

39 (55.7)

p = 0.044

 mainly physical

7 (87.5)

39 (56.5)

31 (44.3)

Current biologic therapy

 no

13 (76.5)

87 (55.4)

74 (61.7)

p = 0.189

 yes

4 (23.5)

70 (44.6)

46 (38.3)

NSAID (last 6 m)

 no

3 (17.6)

55 (35.0)

32 (26.7)

p = 0.160

 yes

14 (82.4)

102 (65.0)

88 (73.3)

DMARD use in past 6 m

 no

10 (58.8)

136 (86.6)a

102 (85.0)

p = 0.011

 yes

7 (41.2)

21 (13.4)

18 (15.0)

 

Mean 95% CI

Mean (95% CI)

Mean (95% CI)

 

Age

 years

49.2 (43.3, 55.0)

47.8 (45.7, 50.0)

50.4 (47.8, 53.0)

p = 0.445

Age at symptom onset

 years

29.3 (25.6, 33.0)

29.7 (27.7, 31.7)

29.7 (27.5, 31.9)

p = 0.873

Disease Activity

 BASDAI: 0 (best) – 10 (worst)

7.8 (7.2, 8.5)

7.4 (7.2, 7.6)

6.0 (5.7, 6.2)

p < 0.001

Disease Activity

 ASDAS

3.8 (3.4, 4.2)

3.9 (3.8, 4.1)

3.3 (3.2, 3.5)

p < 0.001

Physical Function

 BASFI: 0 (best) – 10 (worst)

7.2 (6.3, 8.1)

7.2 (6.9, 7.5)

5.5 (5.1, 5.9)

p < 0.001

Spinal Mobility

 BASMI: 0 (best) – 10 (worst)

4.3 (3.4, 5.1)

4.2 (3.8, 4.6)

4.1 (3.6, 4.6)

p = 0.934

Patient Global

 BASG: 0 (best) – 10 (worst)

7.7 (7.1, 8.3)

7.7 (7.4, 7.9)

6.1 (5.7, 6.5)

p < 0.001

Spinal Pain

 0 (best) – 10 (worst)

6.2 (4.7, 7.6)

7.1 (6.8, 7.4)

5.6 (5.1, 6.0)

p < 0.001

SF12 Mental Component

 100 (best) – 0 (worst)

31.4 (26.6, 36.3)

32.5 (31.1, 34.0)

44.2 (42.5, 45.9)

p < 0.001

SF12 Physical Component

 100 (best) – 0 (worst)

28.9 (25.0, 32.8)

29.9 (28.4, 31.5)

34.3 (32.4, 36.2)

p < 0.001

Quality of Life

 ASQoL: 0 (best) – 18 (worst)

15.4 (14.2, 16.7)

14.6 (14.1, 15.1)

10.9 (10.2, 11.5)

p < 0.001

Work absence

 absenteeism: %

7.0 (1.3, 12.7)

14.2 (8.2, 20.1)

9.3 (4.4, 14.1)

p = 0.737

Work impairment

 presenteeism: %

55.6 (42.4, 68.7)

60.3 (55.1, 65.6)

44.8 (39.8, 49.8)

p < 0.001

Overall work impairment

 %

56.4 (41.3, 71.6)

63.4 (58.0, 68.9)

48.0 (42.7, 53.3)

p < 0.001

Other activity impairment

 %

75.9 (66.4, 85.4)

72.0 (69.4, 74.7)

54.5 (50.2, 58.8)

p < 0.001

  1. asignificant difference between cluster 1 & 2 at p < 0.05