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Table 4 Differences in clinical and patient reported characteristics (not used in clustering) across clusters (fibromyalgia positive participants)

From: AxSpA patients who also meet criteria for fibromyalgia: identifying distinct patient clusters using data from a UK national register (BSRBR-AS)

  Cluster 1 Cluster 2 Cluster 3  
N (%) N (%) N (%) p value
Gender
 male 4 (23.5) 94 (59.9)a 63 (52.5) p = 0.014
 female 13 (76.5) 63 (40.1) 57 (47.5)
Smoking Status
 never 5 (29.4) 53 (34.2) 51 (43.6) p = 0.027
 ex 6 (35.3) 52 (33.5) 48 (41.0)
 current 6 (35.3) 50 (32.3) 18 (15.4)
Alcohol Use
 never 1 (5.9) 21 (13.5) 13 (11.1) p = 0.032
 ex 7 (41.2) 50 (32.3) 21 (18.0)
 current 9 (52.9) 84 (54.2) 83 (70.9)
Employed
 no 8 (47.1) 85 (54.1) 47 (39.5) p = 0.054
 yes 9 (52.9) 72 (45.9) 72 (60.5)
Job type
 mainly sedentary 1 (12.5) 30 (43.5) 39 (55.7) p = 0.044
 mainly physical 7 (87.5) 39 (56.5) 31 (44.3)
Current biologic therapy
 no 13 (76.5) 87 (55.4) 74 (61.7) p = 0.189
 yes 4 (23.5) 70 (44.6) 46 (38.3)
NSAID (last 6 m)
 no 3 (17.6) 55 (35.0) 32 (26.7) p = 0.160
 yes 14 (82.4) 102 (65.0) 88 (73.3)
DMARD use in past 6 m
 no 10 (58.8) 136 (86.6)a 102 (85.0) p = 0.011
 yes 7 (41.2) 21 (13.4) 18 (15.0)
  Mean 95% CI Mean (95% CI) Mean (95% CI)  
Age
 years 49.2 (43.3, 55.0) 47.8 (45.7, 50.0) 50.4 (47.8, 53.0) p = 0.445
Age at symptom onset
 years 29.3 (25.6, 33.0) 29.7 (27.7, 31.7) 29.7 (27.5, 31.9) p = 0.873
Disease Activity
 BASDAI: 0 (best) – 10 (worst) 7.8 (7.2, 8.5) 7.4 (7.2, 7.6) 6.0 (5.7, 6.2) p < 0.001
Disease Activity
 ASDAS 3.8 (3.4, 4.2) 3.9 (3.8, 4.1) 3.3 (3.2, 3.5) p < 0.001
Physical Function
 BASFI: 0 (best) – 10 (worst) 7.2 (6.3, 8.1) 7.2 (6.9, 7.5) 5.5 (5.1, 5.9) p < 0.001
Spinal Mobility
 BASMI: 0 (best) – 10 (worst) 4.3 (3.4, 5.1) 4.2 (3.8, 4.6) 4.1 (3.6, 4.6) p = 0.934
Patient Global
 BASG: 0 (best) – 10 (worst) 7.7 (7.1, 8.3) 7.7 (7.4, 7.9) 6.1 (5.7, 6.5) p < 0.001
Spinal Pain
 0 (best) – 10 (worst) 6.2 (4.7, 7.6) 7.1 (6.8, 7.4) 5.6 (5.1, 6.0) p < 0.001
SF12 Mental Component
 100 (best) – 0 (worst) 31.4 (26.6, 36.3) 32.5 (31.1, 34.0) 44.2 (42.5, 45.9) p < 0.001
SF12 Physical Component
 100 (best) – 0 (worst) 28.9 (25.0, 32.8) 29.9 (28.4, 31.5) 34.3 (32.4, 36.2) p < 0.001
Quality of Life
 ASQoL: 0 (best) – 18 (worst) 15.4 (14.2, 16.7) 14.6 (14.1, 15.1) 10.9 (10.2, 11.5) p < 0.001
Work absence
 absenteeism: % 7.0 (1.3, 12.7) 14.2 (8.2, 20.1) 9.3 (4.4, 14.1) p = 0.737
Work impairment
 presenteeism: % 55.6 (42.4, 68.7) 60.3 (55.1, 65.6) 44.8 (39.8, 49.8) p < 0.001
Overall work impairment
 % 56.4 (41.3, 71.6) 63.4 (58.0, 68.9) 48.0 (42.7, 53.3) p < 0.001
Other activity impairment
% 75.9 (66.4, 85.4) 72.0 (69.4, 74.7) 54.5 (50.2, 58.8) p < 0.001
  1. asignificant difference between cluster 1 & 2 at p < 0.05