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Table 3 Correlations between MSUS/MBDA Score and Clinical Disease Activity Measures

From: Ultrasound and multi-biomarker disease activity score for assessing and predicting clinical response to tofacitinib treatment in patients with rheumatoid arthritis

Baseline MSUS/MBDA score association with Baseline CDAI/DAS28/ESR
  CDAI Baseline DAS28/ESR Baseline
PDUS Baseline 0.53** 0.58**
GSUS Baseline 0.65** 0.53**
mUS7 PDUS Baseline 0.45* 0.58**
mUS7 GSUS Baseline 0.49* 0.42*
MBDA Score Baseline 0.24 0.47*
2 Week MSUS/MBDA score association with 2 Week CDAI/DAS28
  CDAI 2 Week DAS28/ESR 2 Week
PDUS 2 Week 0.45* 0.49*
GSUS 2 Week 0.62** 0.52**
mUS7 PDUS 2 Week 0.43* 0.49*
mUS7 GSUS 2 Week 0.41* 0.31
MBDA Score 2 Week 0.05 0.19
12 Week MSUS/MBDA score association with 12 Week CDAI/DAS28
  CDAI 12 Week DAS28/ESR 12 Week
PDUS 12 Week 0.38 0.54**
GSUS 12 Week 0.52** 0.53**
mUS7 PDUS 12 Week 0.28 0.43*
mUS7 GSUS 12 Week 0.49* 0.44*
MBDA Score 12 Week −0.19 0.05
Baseline MSUS/MBDA score association with 12 Week change in CDAI/DAS28
  CDAI (Δ 0–12 weeks) DAS28/ESR (Δ 0–12 weeks)
PDUS Baseline 0.55** 0.45*
GSUS Baseline 0.47* 0.25
mUS7 PDUS Baseline 0.62** 0.55**
mUS7 GSUS Baseline 0.47* 0.33
MBDA Score Baseline 0.44* 0.50*
2 Week change in MSUS/MBDA score association with 12 Week change in CDAI/DAS28
  CDAI (Δ 0–12 weeks) DAS28/ESR (Δ 0–12 weeks)
PDUS (Δ 0–2 weeks) 0.37 0.42*
GSUS (Δ 0–2 weeks) 0.44* 0.42*
mUS7 PDUS (Δ 0–2 weeks) 0.47* 0.57**
mUS7 GSUS (Δ 0–2 weeks) 0.56** 0.51**
MBDA Score (Δ 0–2 weeks) 0.22 0.29
12 Week change in MSUS/MBDA score association with 12 Week change in CDAI/DAS28
  CDAI (Δ 0–12 week) DAS28/ESR (Δ 0–12 week)
PDUS (Δ 0–12 week) 0.58** 0.56**
GSUS (Δ 0–12 week) 0.47* 0.34
mUS7 PDUS (Δ 0–12 week) 0.60** 0.64**
mUS7 GSUS (Δ 0–12 week) 0.54** 0.48*
MBDA Score (Δ 0–12 week) 0.44* 0.59**
  1. *p < 0.05, **p < 0.01; PDUS Power doppler ultrasound, GSUS Gray scale ultrasound, mUS7 modified ultrasound 7, MBDA Multi-biomarker Disease activity score, CDAI Clinical disease activity index, DAS28/ESR Disease activity score/erythrocyte sedimentation rate