Skip to main content

Table 3 Pain characteristics

From: Clinical and psychological phenomenology of pain in autoinflammatory diseases

Patient number/age/sex/origin Low penetrance variants/mutations Localization of pain Sensory qualities of pain Affective pain quality summary score Pain trigger/ intensifying factors Pain relieving factors Pain severity according to Korff Dis-ability score Dis-ability days De-pression score Anxiety score Actual analgetic therapy
1/68/F/C Q703K (+/−) NLRP3 gene (exon 3) 0 0 13 6 none
2/52/F/C Q703K (+/−) NLRP3 gene (exon 3); R92Q (+/−) TNFRSF1A gene (exon 4) arms, legs, abdominal dragging, burning 1 bacterial/viral infection, mental stress, injury relaxation, yoga, physiotherapy I 0 10 1 6 ibuprofen, diclofenac, acetylsalicylic acid, paracetamol
3/60/F/C Q703K (+/−) NLRP3 gene (exon 3) head, thoracic, lower back, shoulder, arms, hands, legs, feet, abdominal dull, stabbing, dragging, burning 9 mental stress take a walk, sleeping IV 3 8 10 16 ibuprofen, steroids
4/33/M/C Q703K (+/−) NLRP3 gene (exon 3) head, cervical, shoulder dull, stabbing, dragging 6 coldness, mental stress relaxation, stretching III 3 5 3 7 none
5/63/F/C Q703K (+/−) NLRP3 gene (exon 3) lower back, shoulder, pelvic area, legs, feet, pulsatile, throbbing, stabbing, dragging, burning 4 n.k. physio-, ergo-therapy, sleeping, exercising IV 3 90 8 11 none
6/52/F/C Q703K (+/−) NLRP3 gene (exon 3) head, lower back, shoulder, arms, hands, pelvic area, legs, feet dull, dragging 6 mental stress exercising, stress prevention, sleep, relaxation III 1 12 3 4 none
7/40/F/C Q703K (+/−) NLRP3 gene (exon 3) pelvic area dragging 1 fatigue, mental stress relaxation, medication I 0 0.5 11 8 tramadol, ibuprofen, paracetamol, diclofenac
8/47/F/C Q703K (+/−) NLRP3 gene (exon 3) head, cervical, thoracic, lower back, shoulder, pelvic area, legs dull, dragging, burning 1 coldness, physical stress sleep, exercising, change in climate IV 2 30 3 5 none
9/59/F/C Q703K (+/−) NLRP3 gene (exon 3) head, shoulder, arms, hands, pelvic area, legs, feet stabbing, dragging 6 coldness no influence-able factors are known IV 3 20 19 12 ibuprofen
10/29/M/C V726A (+/−) MEFV gene (exon 10) head, cervical, abdominal dragging 7 stress tranquility, mediaction III 1 10 2 3 none
11/49/F/C I591T (+/−)
MEFV gene (exon 9)
head, hands, abdominal dull 5 food nutrition, tranquility, warmness I 0 0 2 7 ibuprofen
12/23/F/C unknown cervical, shoulder, chest dull, pulsatile, stabbing 9 over-exercising, stress, sleep deprivation sleep I 1 14 2 2 none
13/43/F/C M694V (+/−)
MEFV gene (exon 10)
hands, legs, abdominal, chest pulsatile, stabbing, dragging, burning 7 stress sleep IV 3 21 19 16 ibuprofen
14/39/M/C V726A (+/−)
MEFV gene (exon 10)
abdominal dull, pulsatile, stabbing, dragging, burning 12 n.k. no influenceable factors are known IV 3 12 11 7 tramadol, tilidine, oxycodone,
etoricoxib
15/33/F/C I591T (+/−)
MEFV gene (exon 9)
head, cervical, thoracic, lower back, shoulder, arms, hands, pelvic area, legs, feet, abdominal, chest dull, dragging, burning 7 over-exercising, stress meditation, reading, take a walk, meeting friends IV 2 40 3 5 none
16/55/F/C M680I (+/−) MEFV gene (exon 10) thoracic, shoulder, arms, hands, pelvic area, legs, feet dull, stabbing, dragging 9 stress exercise, psychotherapy IV 2 45 9 12 none
17/32/F/C R92Q (+/−) TNFRSF1A gene (exon 4) head, cervical, shoulder, arms, legs dull, pulsatile, stabbing, dragging 5 fatigue, stress take a walk, sleep III 0 42 6 8 ibuprofen
18/55/F/C R92Q (+/+) TNFRSF1A gene (exon 4) hands, feet, abdominal dull, stabbing, dragging 4 warmness take a walk, breathing exercises, distraction II 1 0 9 9 none
19/43/F/C R92Q (+/−) TNFRSF1A gene (exon 4) thoracic, lower back, arms, hands, legs, feet abdominal dull, stabbing, dragging, burning 2 n.k. tranquility, relaxation, medications III 2 0 7 0 none
20/31/F/C R92Q (+/−) TNFRSF1A gene (exon 4) thoracic, arms, hands, pelvic area, legs, feet, abdominal stabbing, dragging 6 weather changes, food intake, mental stress distraction, meditation, exercise IV 2 25 5 5 steroids
21/56/F/C R92Q (+/−) TNFRSF1A gene (exon 4) legs stabbing, pruritic 1 warmness, alcohol, period, stress cold, fresh air, sleep, relaxation, distraction I 1 0 7 5 morphin, tramadol, pregabaline
  1. f female, m male, C Caucasian