Fig. 1

Changes from baseline in sleep as measured by the Jenkins Sleep Evaluation Questionnaire Values are LSM from MMRM. Week 8: PBO, Nx = 101; IXE Q4W, Nx = 95; IXE Q2W, Nx = 101. Week 16: PBO, Nx = 99; IXE Q4W, Nx = 96; IXE Q2W, Nx = 98. Week 36: PBO, Nx = 39; IXE Q4W, Nx = 56; IXE Q2W, Nx = 58. Week 52: PBO, Nx = 34; IXE Q4W, Nx = 53; IXE Q2W, Nx = 52. P values were from MMRM (treatment vs. placebo). * = p < 0.05, ‡ = p < 0.01, † = p < 0.001. IXE Q2W = 80-mg ixekizumab every 2 weeks; IXE Q4W = 80-mg ixekizumab every 4 weeks; IXE Q4W = 80-mg ixekizumab every 2 weeks; LSM = least squares mean; MMRM = mixed-effect model repeated measure; N = number of patients in the treatment group; Nx = number of patients with non-missing values; PBO = placebo