Table 4 Efficacy of GABA derivatives in OA pain management
Study | Pain outcome measures | Summary results |
|---|---|---|
Sofat et al. [15] | NRS, AUSCAN pain score | In intention-to-treat analysis and per protocol analysis, NRS and AUSCAN pain score decreased statistically significantly in pregabalin group compared with placebo group. Only in per protocol analysis NRS score decreased statistically significantly in duloxetine group compared with placebo group |
Ohtori et al. [17] | VAS, WOMAC pain score | Pregabalin and meloxicam reduced VAS and WOMAC pain score of knee OA patient, but there was no statistically significant difference between pregabalin group and meloxicam group. However, a combined use of these two drugs was better than singular use |
Moghaddam et al. [18] | VAS, WOMAC pain score | VAS and WOMAC pain score decreased statistically significantly in gabapentin group and duloxetine group compared with placebo group. However, no statistically significant difference was found in gabapentin group and duloxetine group |