Table 2 Uncorrected and corrected analyses per outcome measure
Outcome | Confounders | |
|---|---|---|
Gout flares | ||
Uncorrected | 0.95 IRR (95% CI 0.80–1.13) | |
Corrected | 0.95 IRR (95% CI 0.78–1.14) | Age, alcohol use, colchicine use, prednisone use, use anti-inflammatory drugs, renal impairment, sUA at baseline, crystal proven gout, presence of tophi and insulin use |
sUA levels baseline | ||
Uncorrected | − 0.02 mmol/l difference (95% CI − 0.05–0.01) | |
Corrected | − 0.02 mmol/l difference (95% CI − 0.04–0.01) | Renal impairment, diuretic use, insulin use and crystal proven gout |
sUA levels over 6 months | ||
Uncorrected | − 0.02 mmol/l difference (95% CI − 0.04–0.00) | |
Corrected | − 0.01 mmol/l difference (95% CI − 0.02–0.01) | sUA at baseline and renal impairment |
Reaching target sUA | ||
Uncorrected | 1.39 OR (95% CI 0.87–2.20) | |
Corrected | 1.09 OR (95% CI 0.66–1.80) | Renal impairment, history of kidney stones sUA at baseline, insulin use and use of diuretics |
Dose at target allopurinol | ||
Uncorrected | 30.4 mg difference (95% CI − 4.7–65.5) | |