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Table 4 Comparison of clinical and laboratory characteristics of SLE patients

From: Association of lipoproteins and thyroid hormones with cognitive dysfunction in patients with systemic lupus erythematosus

SLE characteristics

Low Cognition (n = 48)

High Cognition (n = 33)

P Value

Clinical characteristics

 Globulin, mg/dL

28.18 (±7.97)

27.94 (±6.59)

0.764

 Albumin, mg/dL

31.76 (±5.79)

34.91 (±4.13)

< 0.01**

 24-h urine protein, (g/24 h)

1.97 (±2.59)

1.88 (±3.11)

0.433

 C3 Levels, mg/dL

0.66 (±0.32)

0.77 (±0.29)

0.143

 C4 Levels, mg/dL

0.12 (±0.08)

0.14 (±0.06)

0.323

 LDL-C (mmol/L)

2.77 (±1.37)

2.61 (±1.10)

0.590

 HDL-C (mmol/L)

1.12 (±0.39)

1.33 (±0.55)

0.051

 CRP (mg/dL)

12.36 (±14.00)

11.95 (±16.98)

0.869

 D-dimer (mg/dL)

1.74 (±1.28)

0.75 (±0.82)

< 0.001***

 Cr (μmol/L)

86.95 (±80.42)

66.07 (±36.13)

0.200

 BUN (mmol/L)

8.04 (±5.66)

7.07 (±4.69)

0.491

 UA (μmol/L)

362.20 (±129.73)

339.38 (±142.41)

0.523

 GFR (mL/min/1.73 m2)

117.37 (±56.97)

140.31 (±83.36)

0.223

 ESR (mm/hour)

50.53 (±32.03)

42.59 (±28.74)

0.271

 PLT (109/L)

149.32 (±79.69)

176.09 (±90.84)

0.099

 TSH (mU/L)

2.78 (±2.31)

2.69 (±2.21)

0.830

 FT3 Levels (pmol/L)

3.20 (±1.03)

3.71 (±1.06)

< 0.05*

 FT4 Levels (pmol/L)

12.51 (±3.43)

14.97 (±2.14)

< 0.05*

Blood Cells

 Erythrocyte, (%)

68.66 (±118.01)

40.23 (±66.60)

0.419

 WBC, (109/L)

4.73 (±2.42)

5.43 (±3.62)

0.255

 CD3+ cells, (%)

0.73 (±0.50)

0.67 (±0.40)

0.605

 CD3 + CD4+ cells, (%)

0.33 (±0.22)

0.30 (±0.23)

0.591

 CD3 + CD8+ cells, (%)

0.39 (±0.29)

0.36 (±0.19)

0.563

 B cells, (%)

0.15 (±0.16)

0.10 (±0.13)

< 0.05*

 NK cells, (%)

0.06 (±0.06)

0.06 (±0.04)

0.929

Autoantibodies

 Anti-dsDNA antibodies, U/mL

746.12 (±441.82)

314.56 (±223.99)

< 0.05*

 Anti-Sm antibodies, n (%)

10 (21.28%)

8 (24.24%)

0.754

 Anti-RNP antibodies, n (%)

16 (34.04%)

13 (39.39%)

0.624

 Anti-SSA antibodies, n (%)

19 (40.43%)

14 (42.42%)

0.858

 Anti-SSB antibodies, n (%)

4 (8.51%)

2 (6.06%)

1.000

 Anti-Rib-P, n (%)

10 (21.28%)

11 (33.33%)

0.228

 Anti-β2-GPI, n (%)

1 (2.13%)

0 (0%)

1.000

 IgM (mg/dL)

1.13 (±0.72)

0.76 (±0.41)

< 0.01**

 IgG (mg/dL)

14.52 (±6.79)

12.56 (±5.34)

0.172

 IgA (mg/dL)

2.49 (±1.60)

2.56 (±1.19)

0.857

 IgE (mg/dL)

0.26 (±0.44)

0.23 (±0.41)

0.620

  1. Data are expressed as number (percentage), or mean ± standard deviation (SD) values. P values are based on independent sample t-test and Chi-square test for normally distributed variables. *P < 0.05, **P < 0.01, *** P < 0.005, vs. Low Cognition. The Graph Pad Prism 7.0 and SPSS Statistics 16.0 software were used for statistical analysis
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BMC Rheumatology

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