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  1. Patients with idiopathic inflammatory myopathy and autoantibodies directed against melanoma differentiation-associated protein 5 (MDA5) characteristically have interstitial lung disease, severe cutaneous invol...

    Authors: Meghan E. Ryan, Daniel Cortez, Kelly R. Dietz, Peter Karachunski and Bryce A. Binstadt
    Citation: BMC Rheumatology 2021 5:8
  2. B cells are critical mediators of systemic lupus erythematosus (SLE) and lupus nephritis (LN), and antinuclear antibodies can be found in the serum of approximately 98% of patients with SLE. Spleen tyrosine ki...

    Authors: Christopher W. Pohlmeyer, Ching Shang, Pei Han, Zhi-Hua Cui, Randall M. Jones, Astrid S. Clarke, Bernard P. Murray, David A. Lopez, David W. Newstrom, M. David Inzunza, Franziska G. Matzkies, Kevin S. Currie and Julie A. Di Paolo
    Citation: BMC Rheumatology 2021 5:15
  3. Pyoderma gangrenosum (PG) is an uncommon, idiopathic, ulcerative neutrophilic dermatosis. In many cases, PG is associated with a wide variety of different disorders but SLE in association with PG is relatively...

    Authors: Sing Chiek Teoh, Chun Yang Sim, Seow Lin Chuah, Victoria Kok and Cheng Lay Teh
    Citation: BMC Rheumatology 2021 5:7
  4. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ruth E. Costello, Antonia Marsden, Mohammad Movahedi, Mark Lunt, Jenny H. Humphreys, Richard Emsley and William G. Dixon
    Citation: BMC Rheumatology 2021 5:11

    The original article was published in BMC Rheumatology 2020 4:4

  5. Low dose methotrexate toxicity rarely occurs, but may present with severe complications, such as pancytopenia, hepatotoxicity, mucositis, and pneumonitis. Known risk factors for methotrexate toxicity include d...

    Authors: Miguel A. Jara-Palacios, William Chun and Nomi L. Traub
    Citation: BMC Rheumatology 2021 5:5
  6. Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that causes chronic synovitis, resulting in progressive joint destruction and functional disability and affects approximately 400,000 people in t...

    Authors: Ernest Choy, Lara Groves, Daniel Sugrue, Michael Hurst, John Houghton, Srinivasan Venkatachalam, Yusuf I. Patel, James R. Maxwell, Kevin G. Pollock and Sadie Henning
    Citation: BMC Rheumatology 2021 5:3
  7. Fictional portrayals of illness and medical management in film and television can reflect and perpetuate cultural stereotypes about illness. The aim of this study was to analyse fictional depictions of gout in...

    Authors: Christina Derksen, Rachel Murdoch, Keith J. Petrie and Nicola Dalbeth
    Citation: BMC Rheumatology 2021 5:4
  8. The diagnosis of Behçet disease (BD) is challenging in many cases. The purpose of this study was to describe the clinical characteristics of patients at a referral BD clinic.

    Authors: Mina Kiafar, Seyedeh Tahereh Faezi, Amir Kasaeian, Azarakhsh Baghdadi, Sahar Kakaei, Seyed Ali Mousavi, Mohammad Nejadhosseinian, Farhad Shahram, Seyedeh Zahra Ghodsi, Hormoz Shams and Fereydoun Davatchi
    Citation: BMC Rheumatology 2021 5:2
  9. The activation of antigen specific T cells during an immune response is a tightly regulated process at the level of both costimulatory and coinhibitory receptors. One such coinhibitory receptor or checkpoint i...

    Authors: Mary Canavan, Achilleas Floudas, Douglas J. Veale and Ursula Fearon
    Citation: BMC Rheumatology 2021 5:1
  10. Rheumatoid arthritis (RA) is characterized by systemic inflammation and bone and muscle loss. Recent research showed that obesity facilitates inflammation, but it is unknown if obesity also increases the risk ...

    Authors: Andreas Friedberger, Camille Figueiredo, Tobias Bäuerle, Georg Schett and Klaus Engelke
    Citation: BMC Rheumatology 2020 4:72
  11. Pain is the clinical hallmark of patients in patients with autoinflammatory diseases (AID) caused by variants of the NLRP3-, MEFV- or TNFRSF1A gene. However, no systematical analysis of the clinical and psycholog...

    Authors: Elisabeth Mulazzani, Nicole Zolyniak, Elisabeth Noe, Matthias Mulazzani, Shahnaz Christina Azad, Tania Kümpfel and Eduard Kraft
    Citation: BMC Rheumatology 2020 4:71
  12. Nationally representative data on burden of musculoskeletal conditions (MSK) in Bangladesh are not available. The objective of this study was to determine the prevalence of MSK conditions and related disabilit...

    Authors: Ahmad Zahid-Al-Quadir, M. Mostafa Zaman, Shamim Ahmed, Mahfuzur Rahman Bhuiyan, Md Mujibur Rahman, Ismail Patwary, Bidhu Bhushan Das, Shaikh Amir Hossain, Sujat Paul, Abu Shahin, Moshiur Rahman and Syed Atiqul Haq
    Citation: BMC Rheumatology 2020 4:69
  13. Antineutrophil cytoplasmic antibodies (ANCA) and Anti-glomerular basement membrane (GBM) antibodies often induce rapidly progressive glomerulonephritis (RPGN). Some reports have demonstrated RPGN with the sequ...

    Authors: Mikiya Kato, Risa Wakiya, Tomohiro Kameda, Kousuke Inoue, Tadashi Sofue, Yusuke Ushio, Koichi Sugihara, Shusaku Nakashima, Hiromi Shimada, Mai Mahmoud Fahmy Mansour, Norimitsu Kadowaki and Hiroaki Dobashi
    Citation: BMC Rheumatology 2020 4:68
  14. Takayasu’s arteritis (TA) is a granulomatous, large vessel vasculitis with a preponderance for young women. The inflammation results in disruption of the arterial endothelium causing stenosis, endoluminal thro...

    Authors: Shania Niromi Gunasekera, Chirath Madurapperuma, Nilusha Weerasooriya, Harindra Karunathilake and Ananda Jayanaga
    Citation: BMC Rheumatology 2020 4:66
  15. Patients with rheumatoid arthritis (RA) have high mortality risk and are frequently treated in intensive care units (ICUs).

    Authors: Toshifumi Fujiwara, Kentaro Tokuda, Kenta Momii, Kyohei Shiomoto, Hidetoshi Tsushima, Yukio Akasaki, Satoshi Ikemura, Jun-ichi Fukushi, Jun Maki, Noriyuki Kaku, Tomohiko Akahoshi, Tomoaki Taguchi and Yasuharu Nakashima
    Citation: BMC Rheumatology 2020 4:64
  16. Vascular cell adhesion molecule-1 (VCAM-1) is involved in the progression of glomerular and tubulointerstitial injury in lupus nephritis (LN) and can be easily assessed in urine. The aim of this study was to a...

    Authors: Andrese Aline Gasparin, Nicole Pamplona Bueno de Andrade, Vanessa Hax, Penélope Esther Palominos, Marina Siebert, Romulo Marx, Pedro Guilherme Schaefer, Francisco Veríssimo Veronese and Odirlei André Monticielo
    Citation: BMC Rheumatology 2020 4:67
  17. Reddit is a highly visited social news and discussion website where individuals anonymously ask questions, post opinions and share experiences, which provide a valuable pool of publicly available data. Our obj...

    Authors: Jamie Y. E. Park, Alyssa M. Howren, Eileen Davidson and Mary A. De Vera
    Citation: BMC Rheumatology 2020 4:62
  18. The mixed cryoglobulinemia (MC) syndrome is a systemic inflammatory syndrome that causes small-to-medium vessel vasculitis due to cryoglobulin-containing immune complexes most commonly caused by chronic hepati...

    Authors: Nasam Alfraji, Vandan D. Upadhyaya, Christopher Bekampis and Halyna Kuzyshyn
    Citation: BMC Rheumatology 2020 4:58
  19. The objectives of this study were to describe the profile of ankylosing spondylitis (AS) patients treated with either infliximab (IFX) or subcutaneous golimumab (GLM) treatment in Canadian routine care setting...

    Authors: Proton Rahman, Michael Starr, Derek Haaland, Louis Bessette, Michelle Teo, Emmanouil Rampakakis, Allen J. Lehman and Francois Nantel
    Citation: BMC Rheumatology 2020 4:56
  20. Psoriasis is a chronic inflammatory disease of the skin affecting 2–3% of UK population. 30% of people affected by psoriasis will develop a distinct form of arthritis within 10 years of the skin condition onse...

    Authors: Jesus Miguens Blanco, Federica Borghese, Neil McHugh, Peter Kelleher, Raj Sengupta, Julian R. Marchesi and Sonya Abraham
    Citation: BMC Rheumatology 2020 4:60
  21. The B cell chemoattractant CXCL13 is a promising biomarker in rheumatoid arthritis (RA), with a plausible role in supporting diagnosis, monitoring disease activity and as a prognostic value. It is a key chemok...

    Authors: Katie Bechman, Anthony Dalrymple, Charles Southey-Bassols, Andrew P. Cope and James B. Galloway
    Citation: BMC Rheumatology 2020 4:70
  22. Different proportions of musculoskeletal or autoimmune manifestations associated with COVID-19 have been reported in literature. We performed a systematic review and meta-analysis with the aim of assessing the...

    Authors: Jacopo Ciaffi, Riccardo Meliconi, Piero Ruscitti, Onorina Berardicurti, Roberto Giacomelli and Francesco Ursini
    Citation: BMC Rheumatology 2020 4:65
  23. Access to multidisciplinary pain treatment facilities (MPTF) is limited by extensive waiting time in many countries. However, there is a lack of knowledge about the impact of waiting time on clinical outcomes,...

    Authors: Simon Deslauriers, Jean-Sébastien Roy, Sasha Bernatsky, Debbie E. Feldman, Anne Marie Pinard, François Desmeules, Mary-Ann Fitzcharles and Kadija Perreault
    Citation: BMC Rheumatology 2020 4:59
  24. Many patients with rheumatoid arthritis (RA) do not attain remission/low disease activity, remaining in a moderate disease activity state (MDAS) with ongoing disability and impaired quality of life (QoL). If p...

    Authors: Ian C. Scott, Julie Mount, Jane Barry and Bruce Kirkham
    Citation: BMC Rheumatology 2020 4:63
  25. South Asians have a higher risk of cardiovascular disease (CVD). Rheumatoid arthritis (RA) increases the risk of premature atherosclerosis. We investigated whether there was a substantial difference in the lev...

    Authors: Kanta Kumar, Suvrat Arya, Peter Nightingale, Tom Sheeran and Amita Aggarwal
    Citation: BMC Rheumatology 2020 4:57
  26. Musculoskeletal ultrasound (MSUS) and the multi-biomarker disease activity (MBDA) score are outcome measures that may aid in the management of rheumatoid arthritis (RA) patients. This study evaluated tofacitin...

    Authors: Amir A. Razmjou, Jenny Brook, David Elashoff, Gurjit Kaeley, Soo Choi, Tanaz Kermani and Veena K. Ranganath
    Citation: BMC Rheumatology 2020 4:55
  27. A large number of patients with RA do not adhere to the recommended levels of physical activity to enhance health. According to EULAR recommendations, physical activity should be part of standard care in peopl...

    Authors: Ann Bremander, Karina Malm and Maria L. Andersson
    Citation: BMC Rheumatology 2020 4:53
  28. Blood accessible biomarkers to assess disease activity and their response to therapies in Juvenile Dermatomyositis (JDM) are urgently needed. This pilot study aims to identify serum protein biomarkers associat...

    Authors: Shefa M. Tawalbeh, Wilfredo Marin, Gabrielle A. Morgan, Utkarsh J. Dang, Yetrib Hathout and Lauren M. Pachman
    Citation: BMC Rheumatology 2020 4:52
  29. The idiopathic inflammatory myopathies (IIMs) are chronic autoimmune conditions, typically resulting in proximal muscle weakness and impacting upon quality of life. Accurate measurement of IIM disease activity...

    Authors: Alexander Oldroyd, William Dixon, Hector Chinoy and Kelly Howells
    Citation: BMC Rheumatology 2020 4:47
  30. Long-term clinical registries are essential tools to evaluate new therapies in a patient population that differs from those in randomized clinical trials. The objectives are to describe the profile of rheumato...

    Authors: Proton Rahman, Philip Baer, Ed Keystone, Denis Choquette, Carter Thorne, Boulos Haraoui, Andrew Chow, Rafat Faraawi, Wojciech Olszynski, John Kelsall, Emmanouil Rampakakis, Allen J. Lehman and Francois Nantel
    Citation: BMC Rheumatology 2020 4:46
  31. Cases of exacerbation of pre-existing neuromuscular diseases induced by immune checkpoint inhibitors (ICIs) have rarely been reported because patients with autoimmune diseases have generally been excluded from...

    Authors: Naohiro Uchio, Atsushi Unuma, Toshiyuki Kakumoto, Masao Osaki, Yoshitaka Zenke, Kenichi Sakuta, Akatsuki Kubota, Yoshikazu Uesaka, Tatsushi Toda and Jun Shimizu
    Citation: BMC Rheumatology 2020 4:48
  32. In patients with relapsing polychondritis (RP), organ involvement developed in those with progressive and/or long disease courses. For their management, elucidation of a subgroup suggesting disease progression...

    Authors: Jun Shimizu, Yoshihisa Yamano, Kimito Kawahata and Noboru Suzuki
    Citation: BMC Rheumatology 2020 4:41
  33. To determine whether initiation of a tumor necrosis factor inhibitor (TNFi) or methotrexate improves hemoglobin A1c in patients with psoriatic arthritis (PsA), rheumatoid arthritis (RA), or ankylosing spondyli...

    Authors: Santhi Mantravadi, Michael George, Colleen Brensinger, Min Du, Joshua F. Baker and Alexis Ogdie
    Citation: BMC Rheumatology 2020 4:39
  34. Proteasomes are found in both the cell nucleus and cytoplasm and play a major role in the ubiquitin-dependent and -independent non-lysosomal pathways of intracellular protein degradation. Proteasomes are also ...

    Authors: Hiroshi Maruyama, Kouichi Hirayama, Marina Yamashita, Kentaro Ohgi, Ryuji Tsujimoto, Mamiko Takayasu, Homare Shimohata and Masaki Kobayashi
    Citation: BMC Rheumatology 2020 4:36
  35. Giant cell arteritis (GCA) is a common large vessel vasculitis of the elderly, often associated with sight loss. Glucocorticoids (GC remain the mainstay of treatment, although biologic treatments have been app...

    Authors: Alwin Sebastian, Kornelis S. M. van der Geest, Fiona Coath, Prisca Gondo, Abdul Kayani, Craig Mackerness, Bernard Hadebe, Sue Innes, Jo Jackson and Bhaskar Dasgupta
    Citation: BMC Rheumatology 2020 4:35
  36. The International Classification of Functioning, Disability and Health (ICF) aims to comprehensively describe the ways in which a person’s health condition affects their life. This study aimed to contribute to...

    Authors: Isobel Cairns, Karen Lindsay, Nicola Dalbeth, Cesar Díaz-Torné, Maria Antònia Pou, Basilio Rodríguez Diez, Enriqueta Pujol-Ribera, Charlotte Panter, Rob Arbuckle, Sophi Tatlock and William J. Taylor
    Citation: BMC Rheumatology 2020 4:50
  37. Retroperitoneal fibrosis (RPF) is characterized by the proliferation of fibrous tissue in the retroperitoneum. The majority of RPF cases are due to idiopathic or IgG4-related disease. Recent studies on IgG4-re...

    Authors: Veronika Boyeva, Hatim Alabsi, Michael A. Seidman, Ryan Paterson, Jason Kur, Luke Y. C. Chen, Silvia D. Chang and Mollie Carruthers
    Citation: BMC Rheumatology 2020 4:40
  38. Patients treated for cancer with immune checkpoint inhibitors (ICI) may develop autoimmune adverse events, including ICI-induced inflammatory arthritis (IA). ICI-induced IA treatment requires balancing immune ...

    Authors: Laura C. Cappelli, Suzanne M. Grieb, Ami A. Shah, Clifton O. Bingham III and Ana-Maria Orbai
    Citation: BMC Rheumatology 2020 4:32
  39. To gain insight in the use of current systemic sclerosis (SSc) care provided by health professionals from the patient perspective. We focused on referral reasons, treatment goals, the alignment with unmet care...

    Authors: Juliane K. Stöcker, Madelon C. Vonk, Frank H. J. van den Hoogen, Maria W. G. Nijhuis-van der Sanden, Julia Spierings, J. Bart Staal, Ton Satink and Cornelia H. M. van den Ende
    Citation: BMC Rheumatology 2020 4:43
  40. Dose loading of biological disease modifying anti-rheumatic drugs (bDMARDs) in auto-immune rheumatic diseases (AIRDs) is performed to achieve steady state drug concentrations earlier after treatment start comp...

    Authors: Gerlienke E. Geurts-Voerman, Lise M. Verhoef, Bart J. F. van den Bemt and Alfons A. den Broeder
    Citation: BMC Rheumatology 2020 4:37
  41. Previous studies have linked rheumatoid arthritis (RA) risk and disease activity with vitamin D-deficiency (low serum 25-hydroxyvitamin D (25OHD)), but a causal role for vitamin D in RA is still unclear, with ...

    Authors: Stephanie R. Harrison, Gurpreet Jutley, Danyang Li, Ilfita Sahbudin, Andrew Filer, Martin Hewison and Karim Raza
    Citation: BMC Rheumatology 2020 4:38
  42. Line blot immunoassays (LIA) for myositis-specific (MSA) and myositis-associated (MAA) autoantibodies have become commercially available. In the largest study of this kind, we evaluated the clinical performanc...

    Authors: Fergus To, Clara Ventín-Rodríguez, Shuayb Elkhalifa, James B. Lilleker and Hector Chinoy
    Citation: BMC Rheumatology 2020 4:28

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